Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-2509	Bikinin(Abrasin) CAS:188011-69-0	Bikinin is a non-steroidal,ATP-competitive inhibitor of plant GSK-3/Shaggy-like kinases and activates BR(brassinosteroids)signaling.	price>
R-C-2510	AKT inhibitor IV CAS:959841-49-7	AKT Inhibitor IV promotes hyperphosphorylation of Akt(Protein kinase B), decreases phosphorylation of Akt substrates,and inhibits FOXO1a nuclear export (IC50=625nM in PTEN-null cells).AKT Inhibitor IV inhibits the proliferation of several cells lines(IC50 values are <1.25μM,320-670nM and 340nM for 786-O, HeLa and Jurkat cells,respectively).This compound also displays broad antiviral activity against negative-stranded RNA viruses.	price>
R-C-2570	Zotarolimus CAS:221877-54-9	Zotarolimus(ABT-578)is a derivative of rapamycin(HY-10219),with anti-proliferative activity.Zotarolimus is an immunosuppressant.Zotarolimus is developed specifically for local delivery from stents for the prevention of coronary artery restenosis.	price>
R-C-2691	LB-100 CAS：1026680-07-8	LB-100 is a protein phosphatase 2A(PP2A)inhibitor.LB-100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation.LB-100 enhanced the effects of sorafenib in HCC cells only during hypoxic environments.	price>
R-C-3036	SF1126 CAS:936487-67-1	SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities.Only for scientific research, not for human body.	price>
R-C-2991	Seletalisib cas:1362850-20-1	Seletalisib (UCB5857) is a potent and selective PI3Kδ inhibitor, with IC50 of 12 nM. Seletalisib inhibits T-cell differentiation to Th1, Th2, and Th17 subtypes.Only for scientific research, not for human body.	price>
R-C-2992	Glaucocalyxin A cas:79498-31-0	Glaucocalyxin A is an ent-kauranoid diterpene from Rabdosia japonica var. Glaucocalyxin A induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Only for scientific research, not for human body.	price>
R-C-2993	PQR530 CAS:1927857-61-1	PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 µM.Only for scientific research, not for human body.	price>
R-C-2994	GDC-0077 CAS:2060571-02-8	GDC-0077 is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K. GDC0077 binds to and inhibits various members of the PI3K family, including activating mutations in the catalytic alpha isoform PIK3CA. PI3K inhibition prevents the activation of the PI3K-mediated signaling pathway and results in the inhibition of growth and survival of PI3K-overexpressing tumor cells.Only for scientific research, not for human body.	price>
R-C-2995	Parsaclisib (INCB050465) CAS:1426698-88-5	Parsaclisib (INCB050465) is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib inhibits proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM).Parsaclisib displays significant activity with IC50 values ranging from 0.2 to 2 nM in B and T cell proliferation assays.Only for scientific research, not for human body.	price>

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