Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-R-1078	Yoda 1 CAS No.448947-81-7	Yoda 1/CAS No.448947-81-7 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation.	price>
R-R-1079	Chrysotoxine CAS No.156951-82-5	Chrysotoxine/CAS No.156951-82-5 is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research.	price>
R-R-1080	Albanol B CAS No.87084-99-9	Albanol B/CAS No.87084-99-9 is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2.	price>
R-R-1081	a-Linolenic acid-d14	α-Linolenic acid-d14/CAS No.1622944-40-4 is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer.	price>
R-R-1082	AKT-IN-20 CAS No.473382-50-2	AKT-IN-20/CAS No.473382-50-2 is an AKT inhibitor, and can be used for research of cancer.	price>
R-R-1083	Dipentyl phthalate CAS No.131-18-0	Dipentyl phthalate/CAS No.131-18-0 is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant.	price>
R-R-1084	Midostaurin-d5	Midostaurin-d5 is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM.	price>
R-R-1085	25(R,S)-Ruscogenin CAS No.874485-32-2	25(R,S)-Ruscogenin/CAS No.874485-32-2 from ruixi. Ruscogenin suppresses HCC metastasis by reducing the expression of MMP-2, MMP-9, uPA, VEGF and HIF-1α via regulating the PI3K/Akt/mTOR signaling pathway. And Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by su.	price>
R-R-1086	DCZ3301 CAS.2136278-38-9	DCZ3301/CAS No.2136278-38-9 is a potent aryl-guanidino inhibitor. DCZ3301 inhibits cell proliferation, induces G2/M cell cycle arrest and apoptosis. DCZ3301 inhibits the activation of the PI3K/AKT pathway by downregulating the protein expression of PI3K and phosphorylation of AKT. DCZ3301 can be used in research of cancer.	price>
R-R-1087	(rac)-AG-205 CAS No.442656-02-2	(rac)-AG-205/CAS No.442656-02-2 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway.	price>

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