Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-R-1119	ALM301 CAS No.1313439-71-2	ALM301/CAS No.1313439-71-2 is an orally active highly specific AKT inhibitor with IC50 values of 0.13 µM, 0.09 µM and 2.75 µM for AKT1, AKT2 and AKT3, respectively. ALM301 inhibits AKT phosphorylation and modulates downstream signalling in vitro. ALM301 can inhibit cancer cell proliferation and tumor growth.	price>
R-R-1120	3,4,5-Tricaffeoylquinic acid CAS No.86632-03-3	3,4,5-Tricaffeoylquinic acid/CAS No.86632-03-3 (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases.	price>
R-R-1121	H-Ile-Lys-Val-Ala-Val-OH	H-Ile-Lys-Val-Ala-Val-OH/CAS No.131167-89-0 is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways.	price>
R-R-1122	GSK2110183 analog 1 hydrochloride	GSK2110183/CAS No.2070009-64-0 analog 1 hydrochloride is the structural analogue of GSK2110183.	price>
R-R-1123	NSC45586 sodium CAS No.6300-44-3	NSC45586 sodium/CAS No.6300-44-3 is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 sodium targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons.	price>
R-R-1124	Batatasin III CAS No.56684-87-8	Batatasin III/CAS No.56684-87-8, a stilbenoid, inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition (EMT) and FAK-AKT signals. Batatasin III has anti-cancer activities.	price>
R-R-1125	Quinagolide hydrochloride CAS No.94424-50-7	Quinagolide hydrochloride (CV205-502 hydrochloride)/CAS No.94424-50-7 is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer.	price>
R-R-1126	FPA-124 CAS No.902779-59-3	FPA-124/CAS No.902779-59-3, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis.	price>
R-R-1127	CAY10404 CAS No.340267-36-9	CAY10404/CAS No.340267-36-9 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM and a selectivity index (SI; COX-1 IC50/COX-2 IC50) of >500000. CAY10404 is a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities.	price>
R-R-1128	Bilobetin CAS No.521-32-4	Bilobetin/CAS No.521-32-4, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity.	price>

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