Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-R-1129	A-674563 hydrochloride CAS No.2070009-66-2	A-674563 hydrochloride/CAS No.2070009-66-2 is a potent and selective Akt1 inhibitor with Ki of 11 nM.	price>
R-R-1130	MS21 CAS No.2376137-05-0	MS21, a novel degrader of AKT, selectively inhibits the growth of PI3K/PTEN pathway-mutant cancers with wild-type KRAS and BRAF.	price>
R-R-1131	AT7867 dihydrochloride CAS No.1431697-86-7	AT7867 dihydrochloride/CAS No.1431697-86-7 is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.	price>
R-R-1132	PI3K/Akt/mTOR-IN-2 CAS No.2757804-89-8	PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-2 possess anti-cancer effects and selectivity against MDA-MB-231 cells with IC50 value of 2.29 μM. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and apoptosis.	price>
R-R-1133	Chromeceptin CAS No.331859-86-0	Chromeceptin (94G6)/CAS No.331859-86-0 is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR.	price>
R-R-1134	Crebanine CAS No.25127-29-1	Crebanine/CAS No.25127-29-1, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect.	price>
R-R-1135	Rotundic acid CAS No.20137-37-5	Rotundic acid/CAS No.20137-37-5, a triterpenoid obtained from Ilex rotunda Thunb., induces DNA damage and cell apoptosis in hepatocellular carcinoma through AKT/mTOR and MAPK Pathways. Rotundic acid possesses anti-inflammatory and cardio-protective abilities.	price>
R-R-1136	Cyclovirobuxine D CAS No.860-79-7	Cyclovirobuxine D (CVB-D)/CAS No.860-79-7 is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction.	price>
R-R-1137	PF-AKT400 CAS No.1004990-28-6	PF-AKT400/CAS No.1004990-28-6 is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM).	price>
R-R-1138	CHPG CAS No.170846-74-9	CHPG/CAS No.170846-74-9 is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.	price>

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