Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-R-1109	Miransertib hydrochloride CAS No.1313883-00-9	Miransertib hydrochloride (ARQ-092 hydrochloride)/CAS No.1313883-00-9 is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. Miransertib hydrochloride is also a potent the AKT1-E17K mutant protein inhibitor and has the potential for PI3K/AKT-driven tumors and Proteus syndrome research. Miransertib hydrochloride is effective against Leishmania.	price>
R-R-1110	Fluorofenidone CAS No.848353-85-5	Fluorofenidone (AKF-PD)/CAS No.848353-85-5, an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway.	price>
R-R-1111	SAR125844 CAS No.1116743-46-4	SAR125844/CAS No.1116743-46-4 is a potent, selective, and ATP-competitive MET kinase inhibitor with the value of IC50 is 4.2 nM and Ki is 2.8 nM. SAR125844 has antitumor activity and can be used for the research of cancer.	price>
R-R-1112	Sophocarpine monohydrate CAS No.145572-44-7	Sophocarpine (monohydrate)/CAS No.145572-44-7 is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine (monohydrate) has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer.	price>
R-R-1113	Phellodendrine CAS No.6873-13-8	Phellodendrine/CAS No.6873-13-8, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendron amurense. phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect .	price>
R-R-1114	Alphitolic acid CAS No.19533-92-7	Alphitolic acid (Aophitolic acid)/CAS No.19533-92-7 is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid blocks Akt–NF-κB signaling to induce apoptosis. Alphitolic acid induces autophagy. Alphitolic acid has anti-inflammatory activity and down-regulates the NO and TNF-α production. Alphitolic acid can be used for cancer and inflammation research.	price>
R-R-1115	MKC-1 CAS No.125313-92-0	MKC-1 (Ro-31-7453)/CAS No.125313-92-0 is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family.	price>
R-R-1116	Arnicolide D CAS No.34532-68-8	Arnicolide D/CAS No.34532-68-8 is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner.	price>
R-R-1117	AKT-IN-3 CAS No.2374740-21-1	AKT-IN-3 (compound E22)/CAS No.2374740-21-1 is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells.	price>
R-R-1118	SY-LB-35 CAS No.2603461-70-5	SY-LB-35/CAS No.2603461-70-5 is a potent bone morphogenetic protein (BMP) receptor agonist. SY-LB-35 can stimulate significant increases in cell number and cell viability in the C2C12 myoblast cell line, and causes shifts towards the S and G2/M phases of the cell cycle. SY-LB-35 stimulates canonical Smad and non-canonical PI3K/Akt, ERK, p38 and JNK intracellular signaling pathways.	price>

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