Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-R-1139	AKT-IN-6 CAS No.1430056-54-4	AKT-IN-6 (Example 13)/CAS No.1430056-54-4 is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).	price>
R-R-1140	Phellopterin CAS No.2543-94-4	Phellopterin/CAS No.2543-94-4 is a natural product isolated from Angelica dahurica. Phellopterin reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.	price>
R-R-1141	Crosstide CAS No.171783-05-4	Crosstide/CAS No.171783-05-4 is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt.	price>
R-R-1142	CCT365623 hydrochloride CAS No.2126136-98-7	CCT365623 hydrochloride/CAS No.2126136-98-7 is an orally active lysyl oxidase (LOX) inhibitor, with an IC50 of 0.89 μM. CCT365623 hydrochloride suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF. CCT365623 hydrochloride is extremely well tolerated, and has good pharmacokinetic properties.	price>
R-R-1143	Ipatasertib dihydrochloride CAS No.1396257-94-5	Ipatasertib dihydrochloride (GDC-0068 dihydrochloride)/CAS No.1396257-94-5 is a highly selective and ATP-competitive pan-Akt inhibitor with IC50s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively.	price>
R-R-1144	Pifusertib hydrochloride CAS No.2930090-28-9	Pifusertib (TAS-117) hydrochloride/CAS No.2930090-28-9 is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy.	price>
R-R-1145	Paris saponin VII CAS No.68124-04-9	Paris saponin VII (Chonglou Saponin VII)/CAS No.68124-04-9 is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.	price>
R-R-1147	TD52 CAS No.1798328-24-1	TD52/CAS No.1798328-24-1, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity. TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-1148	Sophocarpine CAS No.6483-15-4	Sophocarpine/CAS No.6483-15-4 is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer.	price>
R-R-1149	M2698 CAS No.1379545-95-5	M2698 (MSC2363318A)/CAS No.1379545-95-5 is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity.	price>

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