Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-R-1161	AS1949490 CAS No.1203680-76-5	AS1949490/CAS No.1203680-76-5 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC50 values of 0.34, 0.62, 13, >50, >50, and >50 µM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes.	price>
R-R-1162	PI3K-IN-46 CAS No.304645-61-2	PI3K-IN-46 (Intermediate 4)/CAS No.304645-61-2 is an intermediate in the synthesis of PI3K inhibitor (2-imino-azolinone-vinyl fused-benzene derivative) that can be used for the research of autoimmune disorders, cardiovascular diseases, and neurodegenerative diseases.	price>
R-R-1163	Pichromene CAS No.883046-50-2	Pichromene (S14161)/CAS No.883046-50-2 is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research.	price>
R-R-1164	Umbralisib R-enantiomer CAS No.1532533-69-9	Umbralisib R-enantiomer (TGR-1202 R-enantiomer)/CAS No.1532533-69-9 is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202.	price>
R-R-1165	WYE-687 dihydrochloride CAS No.1702364-87-1	WYE-687 dihydrochloride/CAS No.1702364-87-1 is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively.	price>
R-R-1166	PI3K-IN-22 CAS No.1202884-94-3	PI3K-IN-22/CAS No.1202884-94-3 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer.	price>
R-R-1167	FD223 CAS No.2050524-24-6	FD223/CAS No.2050524-24-6 is a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor. FD223 displays high potency (IC50=1 nM) and good selectivity over other isoforms (IC50s of 51 nM, 29 nM and 37 nM, respectively for α, β and γ). FD223 exhibits efficient inhibition of the proliferation of acute myeloid leukemia (AML) cell lines by suppressing p-AKT Ser473 thus causing G1 phase arrest during the cell cycle. FD223 has potential for the research of leukemia such as AML.	price>
R-R-1168	IHMT-PI3Ko-372 CAS No.2429889-62-1	IHMT-PI3Kδ-372/CAS No.2429889-62-1 is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can be uesd for chronic obstructive pulmonary disease (COPD) research.	price>
R-R-1169	AS-041164 CAS No.6318-41-8	AS-041164/CAS No.6318-41-8 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects.	price>
R-R-1170	Hirsutenone CAS No.41137-87-5	Hirsutenone/CAS No.41137-87-5 is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity.Hirsutenone/CAS No.41137-87-5 is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity.	price>

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