Product apis-pi3k-akt-mtor

Home > products > apis> pi3k-akt-mtor

Catalog	name	Description	price
R-R-1171	Orobol CAS No.480-23-9	Orobol/CAS No.480-23-9 is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ).	price>
R-R-1173	CHMFL-PI3KD-317 CAS No.2244992-76-3	CHMFL-PI3KD-317/CAS No.2244992-76-3 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3Kγ (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM) and PI4KIIIB (IC50, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells.	price>
R-R-1174	PI3K/mTOR Inhibitor-11 CAS No.2845104-25-6	PI3K/mTOR Inhibitor-11/CAS No.2845104-25-6 is an orally active PI3K/mTOR inhibitor (IC50: 3.5, 4.6, and 21.3 nM for PI3Kα, PI3Kδ, and mTOR). PI3K/mTOR Inhibitor-11 regulates the PI3K/AKT/mTOR signaling pathway by inhibiting the phosphorylation of AKT and S6 proteins. PI3K/mTOR Inhibitor-11 can be used in the research of cancers.	price>
R-R-1175	GSK251 CAS No.2125968-05-8	GSK251/CAS No.2125968-05-8 is a highly potent, highly selective, orally bioavailable inhibitor of PI3Kδ with a novel binding mode.	price>
R-R-1176	Leniolisib phosphate CAS No.1354691-97-6	Leniolisib (CDZ173) phosphate/CAS No.1354691-97-6 is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.	price>
R-R-1177	(S)-PI3Kα-IN-4 CAS No.2322293-84-3	(S)-PI3Kα-IN-4/CAS No.2322293-84-3 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the research of cancer.	price>
R-R-1178	Vulolisib CAS No.2390105-79-8	Vulolisib/CAS No.2390105-79-8 is a potent and orally active phosphatidylinositol 3-kinase (PI3K) inhibitor, with IC50 values of 0.2 nM, 168 nM, 90 nM and 49 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. Antiproliferative and antineoplastic activity.	price>
R-R-1179	Quercetin-d3 CAS No.263711-79-1	Quercetin-d3/CAS No.263711-79-1 is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.	price>
R-R-1180	DS-7423 CAS No.1222104-37-1	DS-7423/CAS No.1222104-37-1 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity.	price>
R-R-1181	(Rac)-AZD 6482 CAS No.663620-70-0	(Rac)-AZD 6482 ((Rac)-KIN-193)/CAS No.663620-70-0 is the racemate of AZD 6482. AZD 6482 is a potent and selective p110β inhibitor with an IC50 of 0.69 nM.	price>

...