Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-R-1192	CAL-130 Hydrochloride CAS No.1431697-78-7	CAL-130 Hydrochloride/CAS No.1431697-78-7 is a PI3Kδ and PI3Kγ inhibitor with IC50s of 1.3 and 6.1 nM, respectively.	price>
R-R-1193	Umbralisib hydrochloride CAS No.1532533-78-0	Umbralisib (TGR-1202) hydrochloride/CAS No.1532533-78-0 is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach.	price>
R-R-1194	CYH33 methanesulfonate CAS No.1494684-33-1	CYH33 methanesulfonate/CAS No.1494684-33-1 is an orally active, highly selective PI3Kα inhibitor with IC50s of 5.9 nM/598 nM/78.7 nM/225 nM against α/β/δ/γ isoform, respectively. CYH33 methanesulfonate inhibits phosphorylation of Akt, ERK and induces significant G1 phase arrest in breast cancer cells and non-small cell lung cancer (NSCLC) cells. CYH33 methanesulfonate has potent activity against solid tumors.	price>
R-R-1195	Risovalisib CAS No.1494684-28-4	Risovalisib (CYH33)/CAS No.1494684-28-4 is an orally active, highly selective PI3Kα inhibitor with IC50s of 5.9 nM/598 nM/78.7 nM/225 nM against α/β/δ/γ isoform, respectively. Risovalisib inhibits phosphorylation of Akt, ERK and induces significant G1 phase arrest in breast cancer cells and non-small cell lung cancer (NSCLC) cells. Risovalisib has potent activity against solid tumors.	price>
R-R-1196	AZD8154 CAS No.2215022-45-8	AZD8154/CAS No.2215022-45-8 is a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease.	price>
R-R-1197	PI3K/mTOR Inhibitor-2 CAS No.1848242-58-9	PI3K/mTOR Inhibitor-2/CAS No.1848242-58-9 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR. Antitumor activity.	price>
R-R-1198	PF-04979064 CAS No.1220699-06-8	PF-04979064/CAS No.1220699-06-8 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.	price>
R-R-1199	Euscaphic acid CAS No.53155-25-2	Euscaphic acid/CAS No.53155-25-2, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM. Euscaphic acid induces apoptosis.	price>
R-R-1200	PI3K/mTOR Inhibitor-4 CAS No.2361215-32-7	PI3K/mTOR Inhibitor-4/CAS No.2361215-32-7 is an orally active pan-class I PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-4 has enzymatic inhibition activity for PI3Kα, PI3Kγ, PI3Kδ and mTOR with IC50 values of 0.63 nM, 22 nM, 9.2 nM and 13.85 nM, respectively. PI3K/mTOR Inhibitor-4 can be used for the research of cancer.	price>
R-R-1201	PKI-179 hydrochloride CAS No.1463510-35-1	PKI-179 hydrochloride/CAS No.1463510-35-1 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 hydrochloride also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 hydrochloride shows anti-tumor activity in vivo.	price>

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