Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-R-1202	Ganoderic acid DM CAS No.173075-45-1	Ganoderic acid DM/CAS No.173075-45-1, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis.	price>
R-R-1203	Tenalisib R Enantiomer CAS No.1639417-54-1	Tenalisib R Enantiomer (RP6530 R Enantiomer)/CAS No.1639417-54-1 is an R enantiomer of Tenalisib. Tenalisib is a potent and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively.	price>
R-R-1204	MTX-211 CAS No.1952236-05-3	MTX-211 (Mol 211)/CAS No.1952236-05-3 is a dual inhibitor of EGFR and PI3K with IC50 values of ＜100 nM. MTX-211 can be used for the research of cancer and other diseases.	price>
R-R-1205	PF-06843195 CAS No.2067281-51-8	PF-06843195/CAS No.2067281-51-8 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts. The Kis of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy.	price>
R-R-1206	ETP-45658 CAS No.1198357-79-7	ETP-45658/CAS No.1198357-79-7 is a potent PI3K inhibitor, with IC50s of 22.0 nM, 39.8 nM, 129.0 nM and 717.3 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. ETP-45658 also can inhibit DNA-PK (IC50=70.6 nM) and mTOR (IC50=152.0 nM). ETP-45658 can be used for the research of cancer.	price>
R-R-1207	4-Methylbenzylidene camphor CAS No.36861-47-9	4-Methylbenzylidene camphor (4-MBC)/CAS No.36861-47-9 is an endocrine disrupter that produces estrogen-like effects. 4-Methylbenzylidene camphor decreases the proliferation of human trophoblast cells and induces apoptosis. 4-Methylbenzylidene camphor activates PI3K/AKT and ERK1/2 signaling pathways and elevates intracellular ROS production. 4-Methylbenzylidene camphor is a ultraviolet (UV) filter and may hamper normal placental formation during early pregnancy.	price>
R-R-1208	Duvelisib (R enantiomer) CAS No.1261590-48-0	Duvelisib R enantiomer/CAS No.1261590-48-0 is a PI3K inhibitor, which is the less active enantiomer of Duvelisib.	price>
R-R-1209	Roginolisib CAS No.1305267-37-1	Roginolisib (MSC2360844; IOA-244)/CAS No.1305267-37-1 is a potent, orally active and selective PI3Kδ inhibitor, with an IC50 of 145 nM. Roginolisib shows highly selective against a panel of 278 additional kinases.	price>
R-R-1210	Pictilisib dimethanesulfonate CAS No.957054-33-0	Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate)/CAS No.957054-33-0 is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).	price>
R-R-1211	YH-306 CAS No.1373764-75-0	YH-306/CAS No.1373764-75-0 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization.	price>

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