Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-R-1222	PI-103 Hydrochloride CAS No.371935-79-4	PI-103 Hydrochloride/CAS No.371935-79-4 is a dual PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy.	price>
R-R-1223	BGT226 maleate CAS No.1245537-68-1	BGT226 (NVP-BGT226 maleate)/CAS No.1245537-68-1 is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ) /mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells.	price>
R-R-1224	hSMG-1 inhibitor 11e CAS No.1402452-10-1	hSMG-1 inhibitor 11e/CAS No.1402452-10-1 is a potent and selective hSMG-1 kinase inhibitor with an IC50 of <0.05 nM. hSMG-1 inhibitor 11e shows >900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM).	price>
R-R-1225	Sonolisib CAS No.502632-66-8	Sonolisib (PX-866)/CAS No.502632-66-8, an improved Wortmannin analogue, is an oral, irreversible, and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)). Antitumor activity.	price>
R-R-1226	Vps34-PIK-III CAS No.1383716-40-2	Vps34-PIK-III/CAS No.1383716-40-2 is an orally active and selective VPS34 inhibitor (IC50=18 nM). Vps34-PIK-III effectively inhibits autophagy and can be used as a molecular tool. vps34-PIK-III is also a PI3K inhibitor that inhibits the expression of genes in liver cancer stem cells (CSCs).	price>
R-R-1227	PI4KIIIbeta-IN-10 CAS No.1881233-39-1	PI4KIIIbeta-IN-10/CAS No.1881233-39-1 is a potent PI4KIIIβ inhibitor with an IC50 of 3.6 nM.	price>
R-R-1228	Ginsenoside Rk1 CAS No.494753-69-4	Ginsenoside Rk1/CAS No.494753-69-4 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures. Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB. Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis. Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway.	price>
R-R-1229	Rigosertib sodium CAS No.592542-60-4	Rigosertib sodium (ON-01910 sodium)/CAS No.592542-60-4 is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. Rigosertib sodium is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM.	price>
R-R-1230	Samotolisib CAS No.1386874-06-1	Samotolisib (LY3023414)/CAS No.1386874-06-1 potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. Samotolisib potently inhibits mTORC1/2 at low nanomolar concentrations.	price>
R-R-1431	Thioridazine-d3 hydrochloride CAS No.1189928-36-6	Thioridazine-d3 (hydrochloride)/CAS No.1189928-36-6 is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs).	price>

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