Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-467	PKI-402 cas:1173204-81-3	PKI-402 is a potent dual pan-PI3K/mTOR inhibitor targeting PI3Kα/β/γ/δ and mTOR with IC50 of 2 nM/7 nM/16 nM/14 nM and 3 nM,respectively;also potent to PI3Kα mutants E545K and H1047R.	price>
R-C-468	GDC0980 CAS:1032754-93-0	GDC-0980 selectively inhibits the activities against class I PI3K and mTOR kinase with a Ki of 17 nM for mTOR (FRAP) and IC50 of 5 nM,27 nM,7nM,and 14 nM for PI3Kα,β,δ,and γ,respectively. GDC-0980 significantly inhibits cell proliferation in PC3 and MCF7 cells.	price>
R-C-472	AZD8055 CAS:1009298-09-2	AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity(∼1,000-fold) against PI3K isoforms and ATM/DNA-PK.AZD8055 induces caspase-dependent apoptosis and also induces autophagy.	price>
R-C-473	KU0063794 CAS:938440-64-3	KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of 10 nM in cell-free assays;no effect on PI3Ks.KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR)(IC50 10 nM for mTORC1 and mTORC2 respectively).	price>
R-C-500	LY294002 cas:154447-36-6	LY294002 (SF 1101,NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/βwith IC50 of 0.5 μM/0.57 μM/0.97 μM,respectively;more stable in solution than Wortmannin,and also blocks autophagosome formation.It not only binds to class I PI3Ks and other PI3K-related kinases,but also to novel targets seemingly unrelated to the PI3K family.LY294002 also inhibits CK2 with IC50 of 98 nM.LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.	price>
R-C-537	TDZD-8 cas:7036-89-5	TDZD-8 is an inhibitor of GSK-3β,with an IC50 of 2 μM;TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II,PKA,and PKC,with all IC50s of >100 μM.	price>
R-C-540	YS-49 cas:132836-42-1	YS-49 is a PI3K/Akt(a downstream target of RhoA)activator,to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells.YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1.YS-49 is also an isoquinoline compound alkaloid,has a strong positive inotropic action through activation of cardiac β-adrenoceptors.	price>
R-C-556	3-Methyladenine (3-MA) cas:5142-23-4	3-Methyladenine (3-MA,NSC 66389) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells;blocks class I PI3K consistently,whereas suppression of class III PI3K is transient,and also blocks autophagosome formation.3-Methyladenine(3-MA)is successfully used to suppress mitophagy.	price>
R-C-557	PHT427 cas:1191951-57-1	PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.	price>
R-C-569	OSI-027 cas:936890-98-1	OSI-027(ASP4786)is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα,PI3Kβ,PI3Kγ or DNA-PK.OSI-027 induces autophagy in cancer cells.	price>

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