Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-576	TWS119 cas:601514-19-6	TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay;capable of inducing neuronal differentiation and may be useful to stem cell biology. GSK-3β inhibition triggers autophagy.	price>
R-C-580	Vistusertib (AZD2014) CAS:1009298-59-2	AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.mTOR kinase inhibitor.	price>
R-C-593	Pictilisib (GDC-0941) cas:957054-30-7	Pictilisib (GDC-0941,RG7321) is a potent inhibitor of PI3Kα/δwith IC50 of 3 nM in cell-free assays,with modest selectivity against p110β(11-fold) and p110γ(25-fold).Pictilisib (GDC-0941) induces autophagy and apoptosis.	price>
R-C-613	BKM-120 cas:944396-07-0	Buparlisib(BKM120;NVP-BKM120)is a pan-class I PI3K inhibitor,with IC50s of 52,166,116 and 262 nM for p110α,p110β,p110δ and p110γ,respectively.	price>
R-C-618	XL-147 cas:934526-89-3	Pilaralisib(XL147;SAR245408)is a potent and highly selective class I PI3Ks inhibitor with IC50s of 39 nM,383 nM,23 nM and 36 nM for PI3Kα,PI3Kβ,PI3Kγ, and PI3Kδ.	price>
R-C-653	AZD1080 cas:612487-72-6	AZD1080 is a novel GSK3 inhibitor,rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.	price>
R-C-666	PF 4708671 CAS： 1255517-76-0	PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase(S6K1 isoform)with Ki/IC50 of 20 nM/160 nM in cell-free assays,400-fold greater selectivity for S6K1 than S6K2,and 4-and>20-fold selectivity for S6K1 than MSK1 and RSK1/2,respectively.PF-4708671 induces autophagy.First S6K1-specific inhibitor to be reported.	price>
R-C-673	OSU-03012 cas:742112-33-0	OSU-03012 is a novel celecoxib derivative,without cyclooxygenase-2 inhibitory activity,capable of inducing apoptosis in various cancer cells types.	price>
R-C-674	P529 cas:914913-88-5	Palomid 529 is a dual TORC1/2 inhibitor of the PI3K/Akt/mTOR pathway having broad activity in angiogenesis and cellular proliferation.	price>
R-C-716	MK2206 cas:1032350-13-2	MK-2206 dihydrochloride(MK-2206 (2HCl))is an orally active allosteric AKT inhibitor with IC50s of 5 nM,12 nM,and 65 nM for AKT1,AKT2, and AKT3,respectively.MK-2206 dihydrochloride induces autophagy.	price>

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