Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-719	BX795 CAS:702675-74-9	BX795 is a potent and selective inhibitor of PDK1,with an IC50 of 6 nM.BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKɛ,with an IC50 of 6 and 41 nM,respectively.BX795 blocks phosphorylation of S6K1,Akt, PKCδ,and GSK3β,and has lower selectivity over PKA,PKC,c-Kit,GSK3β etc.BX795 modulates autophagy.	price>
R-C-723	AR-A014418 CAS:487021-52-3	AR-A 014418 is a selective glycogen synthase kinase 3(GSK-3)inhibitor(IC50=104 nM).Exhibits specificity for GSK-3 over cdk2 and cdk5(IC50 values are>100 μM) and over 26 other kinases.Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.	price>
R-C-729	Capivasertib (AZD5363) CAS No. 1143532-39-1	AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo,has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.	price>
R-C-731	VS-5584 (SB2343) CAS No. 1246560-33-7	VS-5584 is a pan-PI3K/mTOR kinase inhibitor with IC50s of 16 nM,68 nM,42 nM,25 nM,and 37 nM for PI3Kα,PI3Kβ,PI3Kδ,PI3Kγ and mTOR,respectively.VS-5584 simultaneously blocks mTORC2 as well as mTORC1.	price>
R-C-734	SB216763 CAS No. 280744-09-4	SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM(similar potency for GSK3β).	price>
R-C-745	NVP-QAV-572 CAS:957209-68-6	NVP-QAV-572 is a potent PI3K kianse inhibitor with IC50 of 10 nM.	price>
R-C-762	HS-173 cas:1276110-06-5	HS-173,a novel phosphatidylinositol 3-kinase(PI3K)inhibitor,has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis.	price>
R-C-855	Fruquintinib	Fruquintinib is an orally available,small molecule inhibitor of vascular endothelial growth factor receptors(VEGFRs),with potential anti-angiogenic and antineoplastic activities.	price>
R-C-981	A769662 cas:844499-71-4	A-769662 is a potent,reversible AMPK activator with EC50 of 0.8 μM in cell-free assays,little effect on GPPase/FBPase activity.	price>
R-C-983	PS48 cas:1180676-32-7	PS 48 has been shown to be a PKB Kinase(phosphoinositide-dependent protein kinase-1,PDK1)activator(Kd=10.3 μM).Studies have indicated that this compound selectively binds to the PIF-binding pocket of PKB Kinase(PDK1).This is a distinct region separate from the ATP binding site.	price>

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