Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-1119	Liproxstain-1 CAS :950455-15-9	Liproxstatin-1 is an iron droop inhibitor.At a concentration of 50 nm,GPx4-/- MEFs inhibited the iron drooping cell death(IC50=22 nm)and lipid peroxidation of mouse embryonic fibroblasts(MEFs)by inducible knockout of glutathione peroxidase 4(GPx4-/-MEFs).Liproxstatin-1 also inhibited the iron ptosis induced by iron ptosis inducers L-buthionine sulfoxime(BSO),erastine and (1s,3R)-rsl3 in a concentration dependent manner,but did not inhibit necrotic ptosis,apoptosis or necrosis.Inhibition of(1s,3R)-rsl3 induced cell death and lipid peroxidation in human renal proximal tubular epithelial cells.Liproxstatin-1 (10mg/kg)increased survival rate and decreased TUNEL+renal cells in induced GPx4 -/-mice,and reduced tissue damage in liver ischemia/reperfusion injury mice.It is also an antioxidant that inhibits lipid autoxidation by capturing peroxyradicals.	price>
R-C-1123	Dorsomorphin (Compound C) 2HCl	Dorsomorphin 2HCl(BML-275,Compound C)is a potent,reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays,exhibiting no significant inhibition of several structurally related kinases including ZAPK,SYK,PKCθ, PKA,and JAK3.Also inhibits type Ⅰ BMP receptor activity.Dorsomorphin induces autophagy in cancer cell line.	price>
R-C-1149	temsirolimus (CCI-779) CAS：162635-04-3	Temsirolimus is an ester analog of rapamycin.Temsirolimus binds to and inhibits the mammalian target of rapamycin(mTOR),resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle.mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors.	price>
R-C-1167	Tideglusib (NP031112, NP-12) CAS：865854-05-3	Tideglusib(NP031112)is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3βWT(1 h preincubation)and GSK-3βC199A(1 h preincubation), respectively.	price>
R-C-1223	MHY1485 CAS：326914-06-1	MHY1485 is a mTOR activator;inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes.	price>
R-C-1228	KU60019 CAS: 925701-49-1	KU-60019 is an improved analogue of KU-55933,with IC50 of 6.3 nM for ATM in cell-free assays,270-and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.	price>
R-C-1238	ONC201(TIC10) CAS:1616632-77-9	TIC10 is a potent,orally active,and stable tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. TIC10 can cross the blood-brain barrier.	price>
R-C-1257	BIO CAS: 667463-62-9	BIO(GSK-3 Inhibitor IX,6-bromoindirubin-3-oxime,6-Bromoindirubin-3-oxime,MLS 2052)is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/βin a cell-free assay,shows>16-fold selectivity over CDK5,also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2.BIO induces apoptosis in human melanoma cells.	price>
R-C-1270	AZD2858 CAS：486424-20-8	AZD2858 is a potent and GSK-3 inhibitor with an IC50 of 68 nM.AZD-2858 inhibits tau phosphorylation at the S396 site,and it activates Wnt signaling pathway. AZD2858 has a substantial impact on fracture healing.The fractures healed with a bony callus without an obvious endochondral component,suggesting that AZD2858 drives mesenchymal cells into the osteoblastic pathway.	price>
R-C-1297	Ceralasertib (AZD6738) CAS:1352226-88-0	Ceralasertib, also known as AZD6738,is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related(ATR) kinase,with potential antineoplastic activity.Upon oral administration,ATR kinase inhibitor Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1.This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation,disruption of DNA damage repair,and the induction of tumor cell apoptosis.	price>

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