Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-1499	Nemiralisib (GSK2269557) CAS:1254036-71-9	Nemiralisib(GSK2269557 free base)is a potent and highl selective PI3Kδ inhibitor with a pKi of 9.9.	price>
R-C-1500	gsk2292767 CAS:1254036-66-2	GSK2292767 is a potent and selective inhibitor of phosphatidylinositol 3-kinase δ(PI3Kδ;Ki=79pM).GSK2292767 is>100-fold selective for PI3Kδ over a panel of 250 kinases.	price>
R-C-1503	CH5132799 (PA-799) CAS:1007207-67-1	CH5132799(PA-799)is a novel class I PI3K inhibitor,which exhibited a strong inhibitory activity especially against PI3Kα(IC(50)=0.014μM).In human tumor cell lines with PI3K pathway activation,CH5132799 showed potent antiproliferative activity.CH5132799 is orally available and showed significant antitumor activity in PI3K pathway-activated human cancer xenograft models in mice.CH5132799 selectively inhibited class I PI3Ks and PI3Kα mutants in in vitro kinase assays.Tumors harboring PIK3CA mutations were significantly sensitive to CH5132799 in vitro and were remarkably regressed by CH5132799 in in vivo mouse xenograft models.	price>
R-C-1524	Paxalisib (GDC-0084) CAS:1382979-44-3	Paxalisib(GDC-0084,RG7666)is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM,46 nM,3 nM,10 nM and 70 nM for PI3Kα,PI3Kβ,PI3Kδ,PI3Kγ and mTOR.	price>
R-C-1534	AMG319 CAS : 1608125-21-8	AMG-319(ACP319)is a highly selective,potent,and orally bioavailable small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases(PI3K)with potential immunomodulating and antineoplastic activities.PI3K-delta inhibitor AMG 319 prevents the activation of the PI3K signaling pathway through inhibition of the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate(PIP3),thus decreasing proliferation and inducing cell death.	price>
R-C-1541	Rapamycin (Sirolimus) CAS:53123-88-9	Rapamycin(Sirolimus;AY 22989)is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells.Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1.Rapamycin is an autophagy activator,an immunosuppressant.	price>
R-C-1549	Eganelisib (IPI-549) CAS:1693758-51-8	Eganelisib(IPI549)is a potent and selective PI3Kγ inhibitor with an IC50 of 16 nM.Eganelisib shows>100-fold selectivity over other lipid and protein kinases.	price>
R-C-1557	GNE-493 CAS:1033735-94-2	GNE-493 is a potent,selective,and orally available dual pan-PI3-kinase/mTOR inhibitor with IC50s of 3.4 nM,12 nM,16nM,16 nM and 32 nM for PI3Kα,PI3Kβ,PI3Kδ,PI3Kγ and mTOR.	price>
R-C-1570	ETP46464 CAS：1345675-02-6	ETP46464 is an inhibitor of the DNA damage response kinase Ataxia-telangiectasia mutated(ATM)-and Rad3-related(ATR).	price>
R-C-1572	A66 CAS：1166227-08-2	A66 is a potent and highly selective p110α inhibitor with IC50 of 32 nM in a cell-free assay,>100 fold selectivity for p110α over other class-I PI3K isoforms.A66 blocks phosphoinositide 3-kinase signalling and tumour growth in certain cell types.	price>

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