Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-1586	TGX-221 CAS:663619-89-4	TGX-221 is a potent,selective,and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit,used for cancer treatment.	price>
R-C-1634	GSK2110183 CAS:1047644-62-1	Afuresertib(GSK2110183)is an orally bioavailable,selective,ATP-competitive and potent pan-Akt kinase inhibitor with Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3, respectively.	price>
R-C-1637	BAY-1082439 CAS:1375469-38-7	BAY1082439 is an orally bioavailable,selective PI3Kα/β/δ inhibitor. BAY1082439 also inhibits mutated forms of PIK3CA.BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth.	price>
R-C-1648	Miransertib (ARQ-092) CAS:1313881-70-7	Miransertib(ARQ-092)is a potent,selective and orally bioavailable allosteric inhibitor of Akt with IC50s of 2.7nM,14 nM and 8.1nM for Akt1,Akt2,Akt3.	price>
R-C-1673	Idelalisib (CAL-101, GS-1101) CAS:870281-82-6	Idelalisib (CAL-101,GS-1101)is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays;shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ,and 400- to 4000-fold more selectivity to p110δ than C2β,hVPS34,DNA-PK and mTOR.Idelalisib also stimulates autophagy.	price>
R-C-1674	ETC-1002 CAS:738606-46-7	ETC-1002(Bempedoic acid,ESP-55016),also known as Bempedoic acid, is an orally available,once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase(AMPK).It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29uM).	price>
R-C-1697	ETP-46321 CAS：1252594-99-2	ETP-46321 is a potent and orally bioavailable PI3Kα and PI3Kδ inhibitor with Kiapps of 2.3 and 14.2 nM,respectively.	price>
R-C-1772	YY-20394 CAS:1702816-75-8	Linperlisib(YY-20394)is a potent, orally bioavailable and selective inhibitor of PI3Kδ extracted from patent WO 2015055071 A1,compound 10;has an IC50 of 6.4 nM.	price>
R-C-1792	CZ415 CAS:1429639-50-8	CZ415 is a potent and highly selective mTOR inhibitor with a pIC50 of 8.07. CZ415 inhibits mTORC1 and mTORC2 protein complex.	price>
R-C-1866	BAY1895344 CAS:1876467-74-1	Elimusertib(BAY-1895344)is a very potent and highly selective ATR(ataxia telangiectasia and Rad3-related)inhibitor with IC50 of 7nM Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78nM.	price>

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