Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-3024	PI-3065 CAS：955977-50-1	PI-3065 is a selective p110δ inhibitor with IC50 of 15nM,>70-fold selectivity over other PI3K family members.Only for scientific research, not for human body.	price>
R-C-1995	Ipatasertib (GDC-0068) CAS：1001264-89-6	Ipatasertib（GDC-0068)is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt(protein kinase B)with potential antineoplastic activity.Akt inhibitor GDC-0068 binds to and inhibits the activity of Akt in a non-ATP-competitive manner,which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.	price>
R-C-2097	UCB9608 CAS：1616413-96-7	UCB9608 is a potent,selective and orally active PI4KIIIβ inhibitor,with an IC50 of 11 nM,selective over PI3KC2 α,β,and γ lipid kinases.UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent.	price>
R-C-2141	PF 04691502 CAS:1013101-36-4	PF-04691502 is a PI3K/mTOR kinase inhibitor,is also an agent targeting the phosphatidylinositol 3 kinase(PI3K)and mammalian target of rapamycin(mTOR)in the PI3K/mTOR signaling pathway.	price>
R-C-2142	WZ4003 CAS:1214265-58-3	WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100nM for NUAK1(ARK5)/NUAK2,without significant inhibition on other 139 kinases.	price>
R-C-2143	Buparlisib (BKM120) CAS:944396-07-0	Buparlisib(BKM120;NVP-BKM120)is a pan-class I PI3K inhibitor,with IC50s of 52, 166,116 and 262 nM for p110α,p110β,p110δ and p110γ,respectively.	price>
R-C-2145	Tacrolimus (FK506) CAS:104987-11-3	Tacrolimus(FK506,FR900506,Fujimycin,Prograf)is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12(FK506 binding protein)creating a new complex.Tacrolimus also inhibits the phosphatase activity of calcineurin.Tacrolimus induces vascular endothelial autophagy.	price>
R-C-2146	PIK-294 CAS:900185-02-6	PIK-294 is a PI3 Kinase inhibitor that is 20-to 60-fold more potent than the parent compound,PIK-293.It is one of the most potent p110δ-selective inhibitors that has been reported.	price>
R-C-2147	deguelin CAS:522-17-8	Deguelin,a naturally occurring rotenoid,acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt,IKK-NF-κB,and MAPK-mTOR-survivin-mediated apoptosis.Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins,including MEK1/2,Akt,HIF1α,COX-2,and NF-κB.	price>
R-C-2194	PP121 CAS:1092788-83-4	PP121 is a dual inhibitor of receptor tyrosine kinases(RTKs)(IC50<0.02μM for Abl,Src,VEGFR-2 and PDGFR)and PI 3-K family kinases(IC50<0.06μM for p110α,DNA-PK and mTOR).	price>

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