Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-2245	BAY1125976 CAS ： 1402608-02-9	BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.BAY1125976 inhibits the activity of AKT1(IC50=5.2nM at 10µM ATP and 44nM at 2mM ATP) and AKT2(IC50 = 18 nM at 10µM ATP and 36 nM at 2mM ATP)very potently.	price>
R-C-2246	Oridonin (NSC-250682) CAS：28957-04-2	Oridonin(NSC-250682),a diterpenoid isolated from Rabdosia rubescens,acts as an inhibitor of AKT,with IC50s of 8.4 and 8.9μM for AKT1 and AKT2;Oridonin possesses anti-tumor,anti-bacterial and anti-inflammatory effects.	price>
R-C-2248	ABTL-0812 CAS：57818-44-7	ABTL-0812(α-Hydroxylinoleic acid)induces endoplasmic reticulum(ER)stress-mediated autophagy.ABTL-0812 is a first-in-class small molecule with anti-cancer activity.	price>
R-C-2249	AT13148 CAS： 1056901-62-2	AT13148 is an orally active and ATP-competitive,multi-AGC kinase inhibitor with IC50s of 38nM/402 nM/50nM,8nM,3nM,and 6nM/4nM for Akt1/2/3,p70S6K,PKA，and ROCKI/II,respectively.	price>
R-C-3033	CAY10505 CAS:1218777-13-9	CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).Only for scientific research, not for human body.	price>
R-C-3034	D-87503 cas:800394-83-6	D-87503 is a potent PI3K/Akt/mTOR signaling pathway inhibitor with IC50 of 62nM and 0.76μM for PI3K and Erk2, respectively.D-87503 inhibited several carcinoma cell lines, including BxPC3,Hct116, MDA-MB 468 and 231 with EC50 of median 5µM.Only for scientific research, not for human body.	price>
R-C-3035	TG100713 CAS:925705-73-3	TG100713 is a pan-PI3K inhibitor against PI3Kγ,PI3Kδ,PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.Only for scientific research, not for human body.	price>
R-C-3037	CZC24832 CAS:1159824-67-5	CZC24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM,with 10-fold selectivity over PI3Kβ and >100-fold selectivity over PI3Kα and PI3Kδ.Only for scientific research,not for human body.	price>
R-C-3038	AZD6482 CAS: 1173900-33-8	AZD6482 is a potent, selective and ATP competitive PI3Kβ inhibitor (IC(50) 0.01 μm). AZD6482 inhibited insulin-induced human adipocyte glucose uptake in vitro (IC(50) of 4.4 μm). Only for scientific research, not for human body.	price>
R-C-3039	GDC-0032 CAS:1282512-48-4	GDC-0032 is an orally bioavailable, potent and selective inhibitor of Class I PI3Kα, δ and γ isoforms, with 30 fold less inhibition of the PI3K β isoform relative to the PI3Kα isoform. GDC-0032 inhibits MCF7-neo/HER2 cells proliferation with IC50 of 2.5 nM. Only for scientific research, not for human body.	price>

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