Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-2226	Perifosine (KRX-0401)	Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity.Targeting cellular membranes,perifosine modulates membrane permeability,membrane lipid composition,phospholipid metabolism,and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth.This agent also inhibits the anti-apoptotic mitogen-activated protein kinase(MAPK)pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase(SAPK/JNK)pathways,thereby inducing apoptosis.	price>
R-C-2232	Loureirin A CAS：119425-89-7	Loureirin A is a flavonoid extracted from Dragon is Blood,can inhibit Akt phosphorylation,and has antiplatelet activity.	price>
R-C-2233	AT7867 CAS：857531-00-1	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17nM/47nM and 85nM/20nM in cell-free assays,respectively;little activity outside the AGC kinase family.	price>
R-C-2234	Triciribine (NSC 154020) CAS:35943-35-2	Triciribine(VQD-002)is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity.Triciribine inhibits the phosphorylation,activation, and signalling of Akt-1,-2,and-3,which may result in the inhibition of Akt-expressing tumor cell proliferation.Akts are anti-apoptotic serine/theronine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery,including Bcl-xL/Bcl-2-associated death promoter(BAD)and caspase 9.	price>
R-C-2235	CCT128930 CAS： 885499-61-6	CCT128930 is a potent,ATP-competitive and selective inhibitor of Akt2 with IC50 of 6nM in a cell-free assay,28-fold greater selectivity for Akt2 than the closely related PKA kinase.CCT128930 induces cell cycle arrest,DNA damage,and autophagy independent of Akt inhibition.High dose of CCT128930 triggers cell apoptosis in HepG2 cells.	price>
R-C-2236	Miltefosine CAS：58066-85-6	Miltefosine(Hexadecylphosphocholine)inhibits PI3K/Akt activity with ED50 of 17.2μM and 8.1μM in carcinoma cell lines A431 and HeLa,first oral drug for Visceral leishmaniasis,effective against both promastigotes and amastigotes.	price>
R-C-2237	Honokiol (NSC 293100) CAS：35354-74-6	Honokiol is a lignan present in the cones,bark,and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma,sarcoma,myeloma, leukemia,bladder,lung,prostate,oral squamous cell carcinoma and colon cancer cell lines.	price>
R-C-2238	TIC10 isomer CAS：41276-02-2	TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a,possesses superior drug properties:delivery across the blood-brain barrier,superior stability and improved pharmacokinetics.	price>
R-C-2240	Borussertib CAS：1800070-77-2	Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt,with an IC50 of 0.8nM and a Ki of 2.2nM for Aktwt.	price>
R-C-2242	Uprosertib (GSK2141795) CAS：1047634-65-0	Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt,which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.	price>

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