Triciribine (NSC 154020) CAS:35943-35-2

Triciribine(VQD-002)is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity.Triciribine inhibits the phosphorylation,activation, and signalling of Akt-1,-2,and-3,which may result in the inhibition of Akt-expressing tumor cell proliferation.Akts are anti-apoptotic serine/theronine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery,including Bcl-xL/Bcl-2-associated death promoter(BAD)and caspase 9.

msds---Triciribine (NSC 154020)