Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-1299	SC79 CAS:305834-79-1	SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation,in the cytosol,by upstream kinases.SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head.SC-79 injections inhibited alcohol-induced osteonecrosis.Alcohol-induced ONFH is associated with suppression of p-Akt-Ser473 in the Akt/GSK3β/β-catenin signaling pathway in bone mesenchymal stem cells.	price>
R-C-1328	Onatasertib (CC 223) CAS：1228013-30-6	Onatasertib,also known as CC-223,is an orally available inhibitor of the mammalian target of rapamycin(mTOR)with potential antineoplastic activity.mTOR kinase inhibitor CC-223 inhibits the activity of mTOR,which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR,a serine/threonine kinase that is upregulated in a variety of tumors,plays an important role downstream in the PI3K/AKT/mTOR signaling pathway,which is frequently dysregulated in human cancers.	price>
R-C-1351	Alpelisib(BYL719) CAS:1217486-61-7	Alpelisib(BYL-719)is a potent,selective, and orally active PI3Kα inhibitor. Alpelisib(BYL-719)shows efficacy in targeting PIK3CA-mutated cancer.Alpelisib (BYL-719)also inhibits p110α/p110γ/p110δ/p110β with IC50s of 5/250/290/1200 nM,respectively.Antineoplastic activity.	price>
R-C-1361	SC66 CAS：871361-88-5	SC66 is a novel and potent AKT inhibitor,which reduced cell viability in a dose- and time-dependent manner,inhibited colony formation and induced apoptosis in HCC cells.SC66 treatment led to a reduction in total and phospho-AKT levels. SC66 significantly potentiated the effects of both conventional chemotherapeutic and targeted agents,doxorubicin and everolimus,respectively.In vivo,SC66 inhibited tumor growth of Hep3B cells in xenograft models,with a similar mechanism observed in the in vitro model.SC66 had antitumor effects on HCC cells.	price>
R-C-1383	FMK CAS:821794-92-7	FMK is potent,highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2;Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386.Fmk induces significant apoptosis in human FGFR3-expressing,t(4;14)-positive multiple myeloma cells.	price>
R-C-1412	CHIR-98014 CAS:252935-94-7	CHIR-98014 is a potent,cell-permeable GSK-3 inhibitor with IC50s of 0.65 and 0.58 nM for GSK-3α and GSK-3β,respectively;it shows less potent activities against cdc2 and erk2.	price>
R-C-1421	PIK293 CAS:900185-01-5	PIK-293,an analog of IC87114,is a PI3K inhibitor,with IC50 values of 0.24 μM,10μM,25μM and 100μM for p110δ,p110β,p110γ and p110α,respectively.	price>
R-C-1443	Apilimod (STA-5326) CAS：541550-19-0	Apilimod(STA-5326)is a potent and orally-available inhibitor of the cytokines interleukin-12(IL-12)and interleukin-23(IL-23)with the potential to treat certain autoimmune and inflammatory diseases.Apilimod(STA-5326)inhibits IL-12 with IC50 of 1 nM,1 nM and 2 nM,in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs,respectively.Apilimod (STA-5326)is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.	price>
R-C-1447	Torin2 CAS:1223001-51-1	Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/−MEFs cell line;800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties.Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively.Torin 2 decreases cell viability and induces autophagy and apoptosis.	price>
R-C-1474	BX-912 CAS:702674-56-4	BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM,9-and 105- fold greater selectivity for PDK1 than PKA and PKC in cell-free assays, respectively.In comparison to GSK3β,selectivity for PDK1 is 600-fold.	price>

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