Liproxstain-1 CAS :950455-15-9

Liproxstatin-1 is an iron droop inhibitor.At a concentration of 50 nm,GPx4-/- MEFs inhibited the iron drooping cell death(IC50=22 nm)and lipid peroxidation of mouse embryonic fibroblasts(MEFs)by inducible knockout of glutathione peroxidase 4(GPx4-/-MEFs).Liproxstatin-1 also inhibited the iron ptosis induced by iron ptosis inducers L-buthionine sulfoxime(BSO),erastine and (1s,3R)-rsl3 in a concentration dependent manner,but did not inhibit necrotic ptosis,apoptosis or necrosis.Inhibition of(1s,3R)-rsl3 induced cell death and lipid peroxidation in human renal proximal tubular epithelial cells.Liproxstatin-1 (10mg/kg)increased survival rate and decreased TUNEL+renal cells in induced GPx4 -/-mice,and reduced tissue damage in liver ischemia/reperfusion injury mice.It is also an antioxidant that inhibits lipid autoxidation by capturing peroxyradicals.

msds---Liproxstain-1