Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-PV-034	Alisertib	Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation.It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3.MLN8237 is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity	price>
R-C-434	Omipalisib (GSK2126458)	Omipalisib (GSK2126458)is an orally active and highly selective inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ,mTORC1/2,respectively.Omipalisib has anti-cancer activity.	price>
R-C-453	A-674563 CAS:552325-73-2	A-674563 is an Akt1 inhibitor with Ki of 11 nM in cell-free assays,modest potent to PKA and 30-fold selective for Akt1 over PKC.	price>
R-C-455	AS605240 CAS:648450-29-7	AS-605240 selectively inhibits PI3Kγwith IC50 of 8 nM,over 30-fold and 7.5-fold more selective for PI3Kγ than PI3Kδ/β and PI3Kα in cell-free assays, respectively.	price>
R-C-457	Gedatolisib（PKI587） CAS:1197160-78-3	Gedatolisib (pf-05212384,pki-587) is a highly effective dual inhibitor of PI3K α,PI3K γ and mTOR.The IC50 of gedatolisib (pf-05212384,pki-587) is 0.4nm,5.4nm and 1.6nm in cell-free experiment,respectively.Pki-587 also showed potency against the most common PI3K mutation, especially h1047r and e545k,with IC50 of 0.6Nm and 0.6Nm,respectively.The inhibitory effect of pf-05212384 on PI3Ks and mtors inhibited the growth of mda-361 and pc3-mm2 cell lines with IC50 of 4 nm and 13.1 nm,respectively.	price>
R-C-459	GSK690693 CAS:937174-76-0	Gsk690693 is a pan Akt inhibitor targeting AKT1/2/3.The IC50 of gsk690693 is 2 nm /13nm/9 nm in cell-free analysis.Gsk690693 is also sensitive to pKa,PrKX and PKC isozymes of AGC kinase family.Gsk690693 also inhibited AMPK and dapk3 of CaMK family with IC50 of 50nm and 81nm,respectively.	price>
R-C-460	PF-04691502 CAS:1013101-36-4	PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1,p70S6K,MEK,ERK,p38,or JNK. PF-04691502 induces apoptosis.	price>
R-C-462	PP242 CAS:1092351-67-1	Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays;targets both mTOR complexes with>10-and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ,respectively.Torkinib (PP242) induces mitophagy and apoptosis.	price>
R-C-464	YM201636 cas:371942-69-7	YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM.YM-201636 inhibits retroviral replic.	price>
R-C-466	PI-103 cas:371935-74-9	PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays,less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM.PI-103 induces apoptosis in murine T-cell Lymphoma.	price>

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