Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-R-1212	SAR-260301 CAS No.1260612-13-2	SAR-260301/CAS No.1260612-13-2 is an orally available and selective PI3Kβ inhibitor with an IC50 of 23 nM.	price>
R-R-1213	Deoxyshikonin CAS No.43043-74-9	Deoxyshikonin/CAS No.43043-74-9 increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF. Deoxyshikonin inhibited colorectal cancer (CRC) through the PI3K/Akt/mTOR pathway. Deoxyshikonin has proangiogenesis effect and antitumor activity. Deoxyshikonin is an antibacterial agent against methicillin-resistant S. aureus (MRSA) and S. pneumonia (MIC=17 μg/mL).	price>
R-R-1214	PI3K-IN-30 CAS No.2281803-22-1	PI3K-IN-30 (compound 6d)/CAS No.2281803-22-1 is a potent PI3K inhibitor with IC50s of 5.1, 136, 30.7 and 8.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively.	price>
R-R-1215	Buparlisib Hydrochloride CAS No.1312445-63-8	Buparlisib Hydrochloride (BKM120 Hydrochloride)/CAS No.1312445-63-8 is a pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively.	price>
R-R-1216	Vps34-IN-2 CAS No.1523404-29-6	Vps34-IN-2/CAS No.1523404-29-6 is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively. Vps34-IN-2 shows antiviral activity against SARS-CoV-2 (IC50 of 3.1 μM), HCoV-229E (IC50 of 0.7 μM) and HCoV-OC43.	price>
R-R-1217	iMDK quarterhydrate	iMDK quarterhydrate is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice.	price>
R-R-1218	Tenalisib CAS No.1639417-53-0	Tenalisib (RP6530)/CAS No.1639417-53-0 is a novel, potent, and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively.	price>
R-R-1219	Flupentixol dihydrochloride CAS No.2413-38-9	Flupentixol dihydrochloride/CAS No.2413-38-9 is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research.	price>
R-R-1220	Zandelisib CAS No.1401436-95-0	Zandelisib (ME-401)/CAS No.1401436-95-0 is a phosphatidylinositol 3-kinase (PI3K) inhibitor extracted from patent WO2019183226 A1, Compound Example 1. Zandelisib selectively inhibits p110δ with an IC50 of 3.5 nM. Zandelisib functions as an antineoplastic.	price>
R-R-1221	PI4KIIIbeta-IN-9 CAS No.1429624-84-9	PI4KIIIbeta-IN-9/CAS No.1429624-84-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.	price>

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