AKT inhibitor IV CAS:959841-49-7

AKT Inhibitor IV promotes hyperphosphorylation of Akt(Protein kinase B), decreases phosphorylation of Akt substrates,and inhibits FOXO1a nuclear export (IC50=625nM in PTEN-null cells).AKT Inhibitor IV inhibits the proliferation of several cells lines(IC50 values are <1.25μM,320-670nM and 340nM for 786-O, HeLa and Jurkat cells,respectively).This compound also displays broad antiviral activity against negative-stranded RNA viruses.

msds---AKT inhibitor IV