Product apis-neuronal-signaling

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Catalog	name	Description	price
R-C-1517	C-DIM12 CAS:178946-89-9	C-DIM12 is a novel synthetic activator of Nurr1.C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)model of PD in mice.C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown.C-DIM12 increased expression of transfected human Nurr1,induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA.C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons.	price>
R-C-1579	VU0364770 CAS:61350-00-3	VU 0364770 is a positive allosteric modulator(PAM)of mGlu4 with EC50 of 1.1 μM,exhibits insignificant activity at 68 other receptors,including other mGlu subtypes.	price>
R-C-1580	VU0361737 CAS:1161205-04-4	VU 0361737 is a selective positive allosteric modulator(PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors,respectively,displays weak activity at mGlu5 and mGlu8 receptors,is inactive at mGlu1,mGlu2,mGlu3,mGlu6 and mGlu7 receptors,can penetrate into CNS.	price>
R-C-1599	ADX 47273 CAS:851881-60-2	ADX-47273 is a potent,selective and brain-penetrant mGluR5 positive allosteric modulator(PAM),with an EC50 of 0.17 μM for potentiation of glutamate(50nM) response.ADX-47273 has antipsychotic and procognitive activities.	price>
R-C-1627	HG-10-102-01 CAS：1351758-81-0	HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2(LRRK2;IC50=20.3 nM).HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant.HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in cells and is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse brain following intraperitoneal delivery of doses as low as 50 mg/kg.	price>
R-C-1664	TB5 CAS：948841-07-4	TB5 is a MAO-B inhibitor.TB5 showed the inhibitory activity and selectivity toward hMAO-B,with Ki and SI values of 0.11±0.01 μm and 13.18,respectively. TB5 was found to be nontoxic at 5 and 25 μm,with 95.75 and 84.59 % viability among cells,respectively.	price>
R-C-1678	Fosaprepitant dimeglumine CAS：265121-04-8	Fosaprepitant dimeglumine(MK-0517)is a prodrug of Aprepitant(HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist,which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).	price>
R-C-1684	CRT0066101 2HCL CAS：1883545-60-5	CRT0066101 dihydrochloride is a small molecule PKD family specific inhibitor which specifically blocks PKD1/2 activity and does not suppress PKCα/PKCβ/PKCε activity in multiple.	price>
R-C-1688	Basmisanil CAS：1159600-41-5	Basmisanil(RG1662,RO5186582)is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors which is under development by Roche for the treatment of cognitive impairment associated with Down syndrome.As of August 2015,it is in phase II clinical trials for this indication.Down syndrome(DS)is the most commonly identifiable genetic form of intellectual disability.Individuals with DS have considerable deficits in intellectual functioning(i.e.,low intellectual quotient,delayed learning and/or impaired language development)and adaptive behavior.	price>
R-C-1702	Granisetron CAS：109889-09-0	Granisetron(Sancuso,Kevatril,Granisetronum,Sustol)is a serotonin receptor(5HT-3 selective)antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy.	price>

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