Product apis-neuronal-signaling

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Catalog	name	Description	price
R-C-2848	LY 367385 CAS:198419-91-9	LY367385 is a highly selective and potent mGluR1a antagonist.LY367385 has an IC50 of 8.8μM for inhibits of quisqualate-induced phosphoinositide(PI) hydrolysis,compared with >100 μM for mGlu5a.LY367385 has neuroprotective, anticonvulsant and antiepileptic effects.	price>
R-C-456	Dibenzazepine (YO-01027) CAS:209984-56-5	Yo-01027 is a dipeptide type γ-secretase inhibitor with IC50 of 2.6 nm and 2.9 nm,respectively.Yo-01027 is an anti Alzheimer drug.Yo-01027 interacts directly with γ-secretase complex.Different from other γ-secretase inhibitors,yo-01027 targets different functional domains of the complex.Yo-01027 targets the N-terminal presenilin fragment and another gamma secretase inhibitor compound E(CPN E),while dfk167 and dapt bind to the catalytic sites of presenilin aspartate protease subunit and C-terminal presenilin fragment,respectively.In one study,yo-01027 and cpne showed no significant difference in blocking appl and notch cleavage,indicating that the IC50 values of the two substrates were statistically equal.	price>
R-C-458	LY2886721 CAS:1262036-50-9	Ly2886721 is a bace inhibitor for the treatment of Alzheimer disease.The IC50 of recombinant hbace-1 was 20.3 nm.Human BACE2 was inhibited by IC50 of 10.2 nm.It did not inhibit other aspartic proteases,such as cathepsin D,pepsin and renin.A potential drug for Alzheimer disease.The IC50 values of a β 1-40 and a β 1-42 were 18.5 nm and 19.7 nm,respectively,in HEK-293 swe cells and PDAPP neurons (IC50 ~ 10 nm).	price>
R-C-511	JTC801 cas:244218-51-7	JTC-801 is a selective opioid receptor-like1(ORL1) receptor antagonist with IC50 of 94 nM,weakly inhibits receptors δ,κ,and μ.	price>
R-C-522	CTEP (RO4956371) CAS:871362-31-1	CTEP(RO4956371)is a novel,long-acting,orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM,shows >1000-fold selectivity over other mGlu receptors.	price>
R-C-536	VU0364439 cas:1246086-78-1	VU0364439 is a positive allosteric modulator(PAM)of mGlu4 receptors(EC50=19.8 nM in vitro for human mGlu4).	price>
R-C-538	VU0361737 cas:1161205-04-4	VU 0361737 is a selective positive allosteric modulator(PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors,respectively,displays weak activity at mGlu5 and mGlu8 receptors,is inactive at mGlu1,mGlu2,mGlu3,mGlu6 and mGlu7 receptors,can penetrate into CNS.	price>
R-C-541	YM-90K hydrochloride cas:154164-30-4	YM90K hydrochloride is an antagonist of AMPA receptor.	price>
R-C-598	Catharanthine sulfate cas:70674-90-7	Catharanthine is a natural compound isolated from Catharanthus roseus.It exhibits antitumor activity.	price>
R-C-599	Vilazodone cas:163521-12-8	Vilazodone(EMD-68843,SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity.The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine(Ki=56 nM)and dopamine (Ki=37 nM) sites.	price>

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