Product apis-neuronal-signaling

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Catalog	name	Description	price
R-C-1271	Rofecoxib CAS：162011-90-7	Rofecoxib is a nonsteroidal anti-inflammatory drug(NSAID)that has now been withdrawn over safety concerns.Rofecoxib exhibits anti-inflammatory,analgesic, and antipyretic activities in animal models.The mechanism of action of rofecoxib is believed to be due to inhibition of prostaglandin synthesis,via inhibition of cyclooxygenase-2(COX-2).At therapeutic concentrations in humans,rofecoxib does not inhibit the cyclooxygenase-1(COX-1)isoenzyme.Studies to elucidate the mechanism of action of fofecoxib in the acute treatment of migraine have not been conducted.	price>
R-C-1287	YK11 CAS：1370003-76-1	YK-11 is a synthetic,steroidal selective androgen receptor modulator(SARM).It is a gene-selective partial agonist of the androgen receptor(AR)and does not induce the physical interaction between the NTD/AF1 and LBD/AF2(known as the N/C interaction),which is required for full transactivation of the AR.The drug has anabolic activity in vitro in C2C12 myoblasts and shows greater potency than dihydrotestosterone(DHT)in this regard.	price>
R-C-1325	AVN-944 (VX-944) CAS：297730-17-7	AVN-944(VX-944)is an orally available,synthetic small molecule with potential antineoplastic activity.AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH),an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP),a purine molecule required for DNA and RNA synthesis.Inhibition of IMPDH deprives cancer cells of GTP,resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation,and the induction of apoptosis.AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only.IMPDH is overexpressed in some cancer cells,particularly in hematological malignancies.	price>
R-C-1337	FPH2(BRD9424) CAS：957485-64-2	FPH2(BRD-9424)is an inducer of proliferation of primary human hepatocytes.In vitro,FPH2 induced functional proliferation of hepatocytes and might be useful for expanding mature human primary hepatocytes.FPH2(40μM)increased the area of hepatocyte colonies with more hepatocytes and Ki67-positive nuclei,which exhibited hepatocyte nuclear morphologies.In primary human hepatocytes from six additional cell sources,FPH2 increased hepatocytes expansion.FPH2 increased hepatocyte at a rate that is consistent with liver regeneration kinetics in vivo .	price>
R-C-1343	GLYX13 CAS：117928-94-6	Rapastinel,also known as GLYX-13 and BV-102,It is a centrally active, intravenously administered(non-orally active)amidated tetrapeptide(Thr-Pro-Pro-Thr-NH2)that acts as a selective,weak partial agonist(mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax≈25%).	price>
R-C-1367	K858 CAS：72926-24-0	K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent,induces cell death in cancer cells.K858 blocked centrosome separation,activated the spindle checkpoint,and induced mitotic arrest in cells accompanied by the formation of monopolar spindles.Long-term continuous treatment of cancer cells with K858 resulted in antiproliferative effects through the induction of mitotic cell death,and polyploidization followed by senescence.K858 exhibited potent antitumor activity in xenograft models of cancer,and induced the accumulation of mitotic cells with monopolar spindles in tumor tissues.	price>
R-C-1393	Nirogacestat (PF-03084014) CAS：1290543-63-3	Nirogacestat,also known as PF-03084014,is a potent and selective gamma secretase (GS)inhibitor with potential antitumor activity.PF-03084014 binds to GS, blocking proteolytic activation of Notch receptors.Nirogacestat enhances the Antitumor Effect of Docetaxel in Prostate Cancer.Nirogacestat enhances docetaxel-mediated tumor response and provides a rationale to explore GSIs as adjunct therapy in conjunction with docetaxel for men with CRPC(castration-resistant prostate cancer).	price>
R-C-1404	MDL29951 CAS:130798-51-5	MDL 29951 is a novel glycine antagonist of NMDA receptor activation(Ki=0.14 mM, [3H]glycine binding) in vitro and in vivo.	price>
R-C-1455	Betahistine CAS:5638-76-6	Betahistine is a histamine analog and H1 receptor agonist that serves as a vasodilator.It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.Betahistine dihydrochloride is an anti-vertigo drug.It is commonly prescribed for balance disorders or to alleviate vertigo symptoms associated with Ménière is disease.It was first registered in Europe in 1970 for the treatment of Ménière is disease.	price>
R-C-1458	FPS-ZM1 CAS:945714-67-0	FPS-ZM1 is a blood-brain-barrier permeant,non-toxic,tertiary amide compound which is a high affinity RAGE-specific inhibitor,blocking Aβ binding to the V domain of RAGE.	price>

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