Product apis-neuronal-signaling

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Catalog	name	Description	price
R-C-1724	Dastroline(Epinastine) CAS: 80012-43-7	Emedastine is a potent,high affinity histamine H1-receptor-selective antagonist with Ki of 1.3±0.1nM for H1-receptors while considerably weaker at H2-(K1=49,067±11,113nM) and H3-receptors(Ki=12,430±1,282nM).	price>
R-C-1732	Lobeline hydrochloride CAS:134-63-4	Lobeline hydrochloride is an alkaloid that acts on nicotinic cholinergic receptors but is less potent than nicotine.It is also a VMAT2 ligand and an antagonist of μ-opioid receptors.	price>
R-C-1736	Nepafenac CAS:78281-72-8	Nepafenac(AHR 9434,AL 6515)is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity,used in the treatment of pain and inflammation associated with cataract surgery.	price>
R-C-1753	SCH23390 CAS：125941-87-9	SCH-23390 hydrochloride(R-(+)-SCH-23390 hydrochloride)is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2nM and 0.3nM for the D1 and D5 receptor,respectively.SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM.SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors.SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium(GIRK)channels with an IC50 of 268nM.	price>
R-C-1781	JNJ 42153605 CAS：1254977-87-1	JNJ-42153605 is a potent and selective mGlu2 receptor PAM with an acceptable pharmacokinetic profile in rodent and nonrodent species.JNJ-42153605 showed centrally mediated in vivo effectivity in models sensitive to mGlu2 receptor modulation such as sleep−wake electroencephalogram in rats,34 showing suppressed REM sleep during the first 4 h after oral administration of a 3 mg/kg dose.	price>
R-C-1791	Cyantraniliprole (HGW-86) cas:736994-63-1	Cyantraniliprole(HGW-86)is an insecticide of the ryanoid class;has activity against pests such as Diaphorina citri that have developed resistance to other classes insecticides.	price>
R-C-1796	MDL 72527 CAS：93565-01-6	MDL-72527 is a polyamine oxidase(POA)inhibitor that displays anticancer and neuroprotective activity in vivo.	price>
R-C-1803	Lanabecestat (AZD3293)	Lanabecestat(AZD3293)is a potent,orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4nM.Lanabecestat is used for the research of Alzheimer is disease.	price>
R-C-1880	LX-2343 CAS:333745-53-2	LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23μM.LX2343 stimulates autophagy in its promotion of Aβ clearance.	price>
R-C-1895	LOXO-101（Larotrectinib） CAS：1223403-58-4	Larotrectinib(LOXO-101)is an ATP-competitive oral,selective inhibitor of the tropomyosin-related kinase(TRK)family receptors,with low nanomolar 50% inhibitory concentrations against all three isoforms(TRKA,B,and C).	price>

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