Product apis-neuronal-signaling

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Catalog	name	Description	price
R-C-1916	Itanapraced (CHF 5074) CAS:749269-83-8	Itanapraced(CHF 5074,CSP-1103)is a gamma-secretase modulator that reduces Aβ42 and Aβ40 secretion.The IC50s of CHF5074 for inhibition of COX-1 and COX-2 is above 100μmol/L.	price>
R-C-1932	Verubecestat (MK-8931)	Verubecestat(MK-8931)is an orally active,high-affinity BACE1 and BACE2 inhibitor with Ki values of 2.2nM and 0.38nM. Verubecestat effectively reduces Aβ40 and has the potential for Alzheimer is Disease.	price>
R-C-2048	RHC-80267(U-57908) CAS:83654-05-1	RHC 80267(U-57908)is a potent and selective inhibitor of diacylglycerol lipase (DAGL,DAG lipase)with IC50 of 4μM for cholinesterase activity.RHC 80267 inhibits cyclooxygenase(COX)activity,phospholipase C(PLC)activity and the hydrolysis of phosphatidylcholine(PC).	price>
R-C-2072	Astemizole CAS： 68844-77-9	Astemizole is a potent antihistamine(H1-receptor antagonist,IC50=4nM)that displays selectivity over dopamine,5-HT,and muscarinic acetylcholine receptors.This compound has shown potent hERG K+ channel blocking activity (IC50=0.9nM),antimalarial activity in multidrug resistant strains in vitro(IC50=227-734nM),and has been used as a chaperone to correct folding defects and restore protein function for some mutated forms of hERG channels.	price>
R-C-2103	Batefenterol CAS：743461-65-6	Batefenterol(GSK961081;TD-5959)is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist;displays high affinity for hM2,hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4,1.3 and 3.7nM,respectively.	price>
R-C-2129	NBQX CAS： 118876-58-7	NBQX(FG9202)is a highly selective and competitive AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity.	price>
R-C-2137	NVS-ZP7-4 CAS：2349367-89-9	NVS-ZP7-4 is a Zinc transporter SLC39A7(ZIP7)inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.	price>
R-C-2278	Cladribine (RWJ 26251) CAS:4291-63-8	Cladribine(RWJ 26251,Leustatin,2-CdA,2-chlorodeoxyadenosine,2-Chloro-2-deoxyadenosine,CldAdo,Jk 6251,NSC 105014)is an adenosine deaminase inhibitor for U266,RPMI8226,and MM1.S cells with IC50 of approximately 2.43μM,0.75μM,and 0.18μM,respectively.	price>
R-C-2331	Salbutamol CAS:18559-94-9	Salbutamol(Albuterol)is a short-acting,selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis,emphysema,and other lung diseases.	price>
R-C-2332	Brimonidine CAS:59803-98-4	Brimonidine is a drug used as eye drops under the brand names Alphagan and Alphagan-P to treat open-angle glaucoma or ocular hypertension.	price>

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