Rofecoxib CAS：162011-90-7

Rofecoxib is a nonsteroidal anti-inflammatory drug(NSAID)that has now been withdrawn over safety concerns.Rofecoxib exhibits anti-inflammatory,analgesic, and antipyretic activities in animal models.The mechanism of action of rofecoxib is believed to be due to inhibition of prostaglandin synthesis,via inhibition of cyclooxygenase-2(COX-2).At therapeutic concentrations in humans,rofecoxib does not inhibit the cyclooxygenase-1(COX-1)isoenzyme.Studies to elucidate the mechanism of action of fofecoxib in the acute treatment of migraine have not been conducted.

msds---Rofecoxib