Product apis-neuronal-signaling

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Catalog	name	Description	price
R-C-1029	Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) CAS No. 66584-72-3	Ansamitocin P-3 is a microtubule inhibitor,it is also a macrocyclic antitumor antibiotic.Ansamitocin P3 inhibits the proliferation of MCF-7,HeLa,EMT-6/AR1 and MDA-MB-231 cells in culture.Further,Ansamitocin P3 binds to purified tubulin in vitro with a dissociation constant Kd value of 1.3±0.7 µM.	price>
R-C-1043	Rolapitant(sch619734) CAS No. 552292-08-7	SCH-619734 is an orally bioavailable,centrally-acting,selective neurokinin 1 receptor(NK1-receptor)antagonist with a Ki of 0.66 nM.Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system,thereby inhibiting the binding of the endogenous ligand,substance P(SP).Rolapitant is active at 0.1 and 1 mg/kg in both acute and delayed emesis models in ferrets,respectively.	price>
R-C-1045	Ticagrelor (AZD6140) CAS:274693-27-5	Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki=14 nM;IC50=1.8μM),which is the main receptor responsible for ADP-induced platelet aggregation.1,2It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding.3Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.	price>
R-C-1047	lurasidone CAS: 367514-87-2	Lurasidone(SM-13496)is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki=1nM and Ki=0.5 nM,respectively.It also has high affinity for serotonin 5-HT7 receptors(Ki=0.5 nM),partial agonist activity at 5-HT1A receptors(Ki=6.4 nM)and lacks affinity for histamine H1 and muscarinic M1 receptors.	price>
R-C-1050	Lasmiditan (COL-144; LY573144) CAS:439239-90-4	Lasmiditan is is a high-affinity,highly selective 5-HT1F receptor agonist (Ki=2.1nM),compared with Ki of 1043 nM and 1357 nM at the 5-HT(1B)and 5-HT(1D) receptors,respectively.	price>
R-C-2847	SIB 1508Y maleate CAS:192231-16-6	Potent neuronal nicotinic ACh receptor agonist(EC50 values are 1.8,5,9 and 23 nM for α4β2,α2β4,α4β4 and α3β4 receptors respectively).Improves cognitive function in a MPTP-induced model of Parkinson Is Disease in vivo.	price>
R-C-1157	CIQ CAS:486427-17-2	CIQ is a GluN2C/GluN2D subunit-selective NMDA receptor potentiator,which reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice.The facilitation of GluN2C/GluN2D-containing receptors may serve as an important therapeutic strategy for treating positive and cognitive symptoms in schizophrenia.	price>
R-C-1161	Felbamate CAS:25451-15-4	Felbamate(W-554)is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate(NMDA).	price>
R-C-1188	SB742457 CAS: 607742-69-8	Intepirdine,also known as SB-742457 and RVT-101,is a selective 5-HT6 receptor antagonist with potential cognition,memory,and learning-enhancing effects.It was under development by GlaxoSmithKline for the treatment of Alzheimer is disease and demonstrated some preliminary efficacy in phase II clinical trials.SB742457 can reverse age-related declines in delayed non-match-to-sample performance (DNMS).SB742457 shows increasing pro-cognitive effects in patients with AD.	price>
R-C-1234	Blonanserin CAS:132810-10-7	Blonanserin(AD-5423)is a potent and orally active 5-HT2A(Ki=0.812 nM) and dopamine D2 receptor(Ki=0.142nM)antagonist.Blonanserin is usually acts as an atypical antipsychotic agent and can be used for the research of extrapyramidal symptoms,excessive sedation,or hypotension.	price>

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