LY2886721 CAS:1262036-50-9

Ly2886721 is a bace inhibitor for the treatment of Alzheimer disease.The IC50 of recombinant hbace-1 was 20.3 nm.Human BACE2 was inhibited by IC50 of 10.2 nm.It did not inhibit other aspartic proteases,such as cathepsin D,pepsin and renin.A potential drug for Alzheimer disease.The IC50 values of a β 1-40 and a β 1-42 were 18.5 nm and 19.7 nm,respectively,in HEK-293 swe cells and PDAPP neurons (IC50 ~ 10 nm).

MSDS---LY2886721