HG-10-102-01 CAS：1351758-81-0

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2(LRRK2;IC50=20.3 nM).HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant.HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in cells and is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse brain following intraperitoneal delivery of doses as low as 50 mg/kg.

msds---HG-10-102-01