Product apis-jak-stat

Home > products > apis> jak-stat

Catalog	name	Description	price
R-C-2166	Upadacitinib (ABT-494) CAS:1310726-60-3	Upadacitinib（ABT-494)is a potent and selective JAK inhibitors in development for rheumatoid arthritis.ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific,relevant cytokines.ABT-494 demonstrates efficacy in rat arthritis models.	price>
R-C-2167	Abrocitinib (PF-04965842) CAS:1622902-68-4	Abrocitinib(PF-04965842)is a potent,orally active and selective JAK1 inhibitor, with IC50s of 29 and 803nM for JAK1 and JAK2,respectively.Abrocitinib(PF-04965842)exhibits less active effect on TYK2(IC50,1.253μM),and inhibits phosphorylation of STAT1,STAT3 and STAT5 after stimulation.Effective in autoimmune disease.	price>
R-C-2168	Itacitinib (INCB39110) CAS:1334298-90-6	INCB39110 is a potent JAK1 tyrosine kinase inhibitor,which is currently in Phase II trials for the treatment of rheumatoid arthritis,myelofibrosis,rheumatoid arthritis and plaque psoriasis.	price>
R-C-2230	Hispidulin CAS:1447-88-7	Hispidulin(Dinatin),an active natrual ingredient in a number of traditional Chinese medicinal herbs,exhibits inhibitory activity against the oncogenic protein kinase Pim-1 with IC50 of 2.71μM.Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells.Hispidulin exerts anti-osteoporotic and bone resorption attenuating effects via activating the AMPK signaling pathway.	price>
R-C-2247	Scutellarin CAS： 27740-01-8	Scutellarin(Breviscapine,Breviscapin,Scutellarein-7-glucuronide),the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus(Vant.)Hand-Mazz,has many pharmacological effects,such as antioxidant,antitumor,antiviral,and antiinflammatory activities.Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells,and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.	price>
R-C-2385	Ruxolitinib (INCB018424) CAS：941678-49-5	Ruxolitinib(INCB018424)is the first potent,selective,JAK1/2 inhibitor to enter the clinic with IC50 of 3.3nM/2.8nM in cell-free assays,>130-fold selectivity for JAK1/2 versus JAK3.Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.	price>
R-C-2386	Cucurbitacin I CAS：2222-07-3	Cucurbitacin-I(Elatericin B,JSI 124,NSC 521777),a natural cell-permeable triterpenoid isolated from Cucurbitaceae,is a novel selective inhibitor of JAK2/STAT3.	price>
R-C-2562	HO-3867 CAS：1172133-28-6	HO-3867 is a selective and potent STAT3 inhibitor.HO-3867 selectively inhibited STAT3 phosphorylation,transcription,and DNA binding without affecting the expression of other active STATs.HO-3867 exhibited minimal toxicity toward noncancerous cells and tissues but induced apoptosis in ovarian cancer cells.	price>
R-C-2563	STATTIC CAS：19983-44-9	Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation(at Y705 and S727).Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3.Stattic ameliorates the renal dysfunction in Alport syndrome (AS)mice.	price>
R-C-2692	NVP-BSK805 CAS：1092499-93-8	NVP-BSK805 is a JAK2 inhibor,which displays more than 20-fold selectivity towards JAK2 in vitro,as well as excellent selectivity in broader kinase profiling.In vivo,NVP-BSK805 exhibited good oral bioavailability and a long half-life.	price>

...