Product apis-jak-stat

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Catalog	name	Description	price
R-R-1481	Fedratinib hydrochloride hydrate CAS No.1374744-69-0	Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate)/CAS No.1374744-69-0 is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib hydrochloride hydrate induces cancer cell apoptosis and has the potential for myeloproliferative disorders research.	price>
R-C-539	TCS PIM-1 4a CAS: 438190-29-5	TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor(IC50 values=24 and 100 nM for Pim-1 and Pim-2,respectively).	price>
R-C-551	(NSC 42834)JAK2 Inhibitor V Z3 CAS :195371-52-9	NSC 42834(JAK2 Inhibitor V,Z3) is a novel specific inhibitor of Jak2,inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.	price>
R-R-2262	AG490 CAS No.133550-30-8	AG490 (Tyrphostin AG490)/CAS No.133550-30-8 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.	price>
R-R-2263	Coumermycin A1 CAS No.4434-05-3	Coumermycin A1/CAS No.4434-05-3 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.	price>
R-R-2264	SJ1008030 TFA CAS No.2863634-97-1	SJ1008030 (compound 8) TFA/CAS No.2863634-97-1 is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 TFA inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 TFA can be used for the research of leukemia.	price>
R-R-2265	Ruxolitinib phosphate CAS No.1092939-17-7	Ruxolitinib phosphate (INCB018424 phosphate)/CAS No.1092939-17-7 is a potent JAK1/2 inhibitor with IC50s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity over JAK3.	price>
R-R-2266	Ritlecitinib CAS No.1792180-81-4	Ritlecitinib/PF-06651600/CAS No.1792180-81-4 is an orally active and selective JAK3 inhibitor with an IC50 of 33.1 nM.	price>
R-R-2267	Butyzamide CAS No.1110767-45-7	Butyzamide/CAS No.1110767-45-7 is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay.	price>
R-R-2268	RO8191 CAS No.691868-88-9	RO8191 (CDM-3008)/CAS No.691868-88-9, an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity.	price>

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