Product apis-jak-stat

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Catalog	name	Description	price
R-R-2278	AZ960 CAS No.905586-69-8	AZ960/CAS No.905586-69-8 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM.	price>
R-R-2279	Brepocitinib P-Tosylate CAS No.2140301-96-6	Brepocitinib (PF-06700841) P-Tosylate/CAS No.2140301-96-6 is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib P-Tosylate also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively.	price>
R-R-2280	BMS-986202 CAS No.1771691-34-9	BMS-986202/CAS No.1771691-34-9 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 value of 0.19 nM and a Ki of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC50 value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium.	price>
R-R-2281	Izencitinib CAS No.2051918-33-1	Izencitinib (TD-1473)/CAS No.2051918-33-1 is an orally active, non-selective and gut-restricted JAK inhibitor. Izencitinib (TD-1473) can be used in the study for ulcerative colitis.	price>
R-R-2282	Golidocitinib CAS No.2091134-68-6	AZD4205/CAS No.2091134-68-6 is a selective inhibitor of JAK1, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM).	price>
R-R-2283	Ilginatinib CAS No.1239358-86-1	Ilginatinib (NS-018)/CAS No.1239358-86-1 is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).	price>
R-R-2284	(Z)-LFM-A13 CAS No.244240-24-2	LFM-A13/CAS No.244240-24-2 is a potent BTK, JAK2, PLK inhibitor, inhibits recombinant BTK, Plx1 and PLK3 with IC50s of 2.5 μM, 10 μM and 61 μM; LFM-A13 shows no effects on JAK1 and JAK3, Src family kinase HCK, EGFR and IRK.	price>
R-R-2285	Solcitinib CAS No.1206163-45-2	Solcitinib/CAS No.1206163-45-2 is an orally active, competitive, potent, selective JAK1 inhibitor, with an IC50 of 9.8 nM, and 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively; Solcitinib is used in the research of moderate-to-severe plaque-type psoriasis.	price>
R-R-2286	Gusacitinib CAS No.1425381-60-7	Gusacitinib (ASN-002)/CAS No.1425381-60-7 is a dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) that is orally active and potent with IC50 values of 5-46 nM. Gusacitinib has anticancer activity in both solid and hematologic tumor types.	price>
R-R-2287	Tyk2-IN-5 CAS No.1797432-62-2	Tyk2-IN-5 (compound 6)/CAS No.1797432-62-2 is a potent, selective and orally active tyrosine kinase 2 (Tyk2) inhibitor that acts on the JH2 structural domain. Tyk2-IN-5 shows a Ki value of 0.086 nM for Tyk2 JH2 and an IC50 value of 25 nM for IFNα. Tyk2-IN-5 efficiently inhibits the production of IFNγ in a pharmacodynamic rat model and is fully efficacious in a rat model of arthritis.	price>

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