Product apis-jak-stat

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Catalog	name	Description	price
R-C-2699	AZD1208 CAS：1204144-28-4	AZD1208 is orally available,small molecule inhibitor of PIM kinases with potential antineoplastic activity.Pan-PIM kinase inhibitor AZD1208 inhibits the activities of PIM1,PIM2 and PIM3 serine/threonine kinases,which may result in the interruption of the G1/S phase cell cycle transition,thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs.	price>
R-C-2704	Cercosporamide CAS：131436-22-1	Cercosporamide,an usnic amide,was originally identified in Cercosporidium henningsii as a host-selective phytotoxin and broad-spectrum antifungal agent and is a potent inhibitor of MAP-kinase interacting kinase-2(Mnk2;IC50=11 nM),JAK3(IC50=31),and Mnk1(IC50=116nM).	price>
R-C-2714	BMS-911543 CAS:1271022-90-2	BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase(JAK)with potential antineoplastic activity.JAK2 inhibitor BMS-911543 selectively inhibits JAK2,thereby preventing the JAK/STAT(signal transducer and activator of transcription)signaling cascade,including activation of STAT3.This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation.	price>
R-C-2715	AZD-9291 (Osimertinib) CAS:1271022-90-2	AZD-9291 is a third-generation EGFR inhibitor,showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.	price>
R-C-2719	AEE788 (NVP-AEE788)	AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor(EGFR),human epidermal growth factor receptor 2(HER2),and vascular endothelial growth factor receptor 2(VEGF2),resulting in receptor inhibition, the inhibition of cellular proliferation,and induction of tumor cell and tumor-associated endothelial cell apoptosis.	price>
R-C-2720	Niclosamide CAS:50-65-7	Inhibitor of the STAT3 signaling pathway;inhibits the activation,nuclear translocation and transactivation of STAT3.Displays selectivity for STAT3 over STAT1,STAT5,JAK1,JAK2 and Src kinases.Inhibits the transcription of STAT3 target genes and induces cell growth inhibition,apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3.Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro;displays antineoplastic effects in acute myelogenous leukemia(AML)stem cells.	price>
R-C-2721	NSC 74859 CAS:501919-59-1	S3I-201(NSC 74859)is a novel inhibitor of Stat3 that inhibits Stat3,Stat3 complex formation and Stat3-DNA binding activity in vitro(IC50=86±33µM)and Stat3-dependent transcriptional activities.	price>
R-C-2723	AC480 (BMS-599626) CAS:714971-09-2	BMS-599626(AC480)is a selective and orally bioavailable HER1 and HER2 inhibitor,with IC50s of 20 and 30nM,respectively.BMS-599626 displays~8-fold less potent to HER4(IC50=190nM),>100-fold to VEGFR2,c-Kit,Lck,MEK. BMS-599626 inhibits tumor cell proliferation,and has potential to increase tumor response to radiotherapy.	price>
R-C-2724	Corylifol A CAS:775351-88-7	Corylifol A is a phenolic compounds isolated from Psoralea corylifolia;inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8uM).	price>
R-C-2725	BMS-690514 CAS:859853-30-8	BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor(EGFR),HER2,and HER4，as well as the VEGF receptor kinases.	price>

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