Product apis-jak-stat

Home > products > apis> jak-stat

Catalog	name	Description	price
R-R-2422	Nifuroxazide-d4 CAS No.1188487-83-3	Nifuroxazide-d4/CAS No.1188487-83-3 is the deuterium labeled Nifuroxazide. Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity.	price>
R-R-2423	Galiellalactone CAS No.133613-71-5	Galiellalactone/CAS No.133613-71-5 is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer.	price>
R-R-2424	HJC0416 hydrochloride CAS No.2415263-08-8	HJC0416 hydrochloride/CAS No.2415263-08-8 is a potent and orally active STAT3 inhibitor with an enhanced anticancer profile than Stattic (HY-13818). HJC0416 hydrochloride is a promising anti-cancer agent for breast cancer study.	price>
R-C-749	TCS PIM-1 1 cas:491871-58-0	TCS PIM-1 1(SC 204330) is a potent,selective and ATP-competitive Pim-1 kianse inhibitor with an IC50 of 50 nM,displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s >20000 nM).	price>
R-C-750	NVP-BSK805 2HCl CAS No. 1942919-79-0	NVP-BSK805 is a potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor that potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.	price>
R-C-997	WHI-P154 cas:211555-04-3	WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50=1.8 μM versus IC50s>10 μM for JAK1 and JAK2).1It has been reported to inhibit additional kinases including EGFR (IC50= 4 nM)and VEGFR as well as the non-receptor tyrosine kinases,Abl,Lck,and Src.1WHI-P154 is cytotoxic to human glioblastoma cells(IC50=813 nM) and has been used to induce the differentiation of neuronal precursor cells.	price>
R-C-1068	Gandotinib (LY2784544) CAS:1229236-86-5	LY2784544 is a small molecule selective mutant JAK2 kinase inhibitor with an IC50 of 68 nM.The antiproliferative activity of LY2784544 and its ability to induce apoptosis were examined by Celltiter-Glo Cell Viability and Caspase-Glo 3/7 Apoptosis Assays,respectively.In the in vitro tests using Ba/F3 cells expressing either wild type or V617F mutant JAK2,it potently inhibited the JAK2 V617F-STAT5 signaling at a concentration that was 41-fold lower than that required to inhibit IL-3-activated wild type JAK2-STAT5 signaling(IC50=0.055 uM for JAK2 V617F vs.2.26 uM for WT JAK2).Similarly in the proliferation assay, LY2784544 selectively inhibited the JAK2 V617F-driven cell proliferation(IC50= 0.068 uM).Inhibition of JAK2 V617F signaling correlated well with the induction of apoptosis(EC50=0.113 uM)in Ba/F3 cell model.	price>
R-C-1072	CX-6258HCL CAS:1353859-00-3	CX-6258 HCl is a potent,orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM,25 nM and 16 nM for Pim1,Pim2,and Pim3.	price>
R-C-1129	Baricitinib(LY3009104) CAS :1187594-09-7	Baricitinib(LY3009104,INCB028050)is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays,~70 and ~10-fold selective versus JAK3 and Tyk2,no inhibition to c-Met and Chk2.	price>
R-C-1250	GLPG0634 analogue CAS：1206101-20-3	GLPG0634-analogue is an analogue of Filgotinib or GLPG0634,is a potent and selective JAK1 inhibitor.	price>

...