Product apis-jak-stat

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Catalog	name	Description	price
R-C-1704	SH5-07 (SH-5-07) CAS:1456632-41-9	SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor,which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.	price>
R-C-1706	BP-1-102 CAS:1334493-07-0	BP-1-102 is a potent,orally bioavailable and selective STAT3 inhibitor,binds Stat3 with an affinity Kd of 504nM and blocks Stat3-phospho-tyrosine(pTyr) peptide interactions and Stat3 activation at 4-6.8μM.	price>
R-C-1725	Peficitinib CAS: 944118-01-8	Peficitinib is a novel potent JAK inhibitor,which demonstrated potent efficacy in adjuvant-induced arthritis model in rats.	price>
R-C-1857	FM-381 CAS:2226521-65-7	FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909.FM-381 has an IC50 of 127 pM for JAK3,with 410,2700 and 3600-fold selectivity over JAK1,JAK2 and TYK2,respectively.	price>
R-C-1861	SGI-1776 CAS:1025065-69-3	SGI-1776 is a small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity.Pim kinase inhibitor SGI-1776 binds to and inhibits the activities of Pim-1,-2 and -3,serine-threonine kinases,which may result in the interruption of the G1/S phase cell cycle transition,the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis.PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.	price>
R-C-1899	C188-9 CAS：432001-19-9	C188-9(TTI 101)is a potent inhibitor of STAT3 that binds to STAT3 with high affinity(KD=4.7±0.4nM).C188-9 is well tolerated in mice,shows good oral bioavailability,and is concentrated in tumors.	price>
R-C-1908	SAR-20347 CAS：1450881-55-6	SAR-20347 is a potent inhibitor of TYK2,JAK1,JAK2 and JAK3 with IC50 of 0.6 nM,23nM,26nM and 41nM,respectively.SAR-20347 inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signaling.	price>
R-C-1910	Cerdulatinib CAS：1198300-79-6	Cerdulatinib(PRT-062070)is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12nM/6nM/8 nM/0.5nM and 32nM for JAK1/JAK2/JAK3/TYK2 and Syk.	price>
R-C-2162	AZD1480 CAS:935666-88-9	AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2(JAK2)with potential antineoplastic activity.JAK2 inhibitor AZD1480 inhibits JAK2 activation,leading to the inhibition of the JAK/STAT(signal transducer and activator of transcription)signaling including activation of STAT3.	price>
R-C-2165	TG101209 CAS:936091-14-4	TG101209 is a selective JAK2 inhibitor with IC50 of 6nM, less potent to Flt3 and RET(c-RET)with IC50 of 25 nM and 17nM in cell-free assays,~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.	price>

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