Product apis-jak-stat

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Catalog	name	Description	price
R-C-1290	Filgotinib (GLPG0634) CAS：1206161-97-8	Filgotinib,also known as GLPG0634,is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis(RA)and Crohn is disease.It is considered a promising agent as it inhibits JAK1 selectively. Filgotinib displayed a selectivity of 30-fold for JAK1-over JAK2-dependent signaling.GLPG0634 dose-dependently inhibited Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro.	price>
R-C-1309	WP1066 CAS:857064-38-1	WP1066 is a Stat3 inhibitor and JAK2 inhibitor.WP1066 is also a novel analogue of the JAK2 inhibitor AG490,in JAK2 V617F-positive erythroleukemia HEL cells and in blood cells from patients with polycythemia vera.WP1066 significantly inhibited JAK2 and its downstream signal transducer and activator of transcription-3,signal transducer and activator of transcription-5,and extracellular signal-regulated kinase-1/2 pathways in a dose-and time-dependent manner.	price>
R-C-1397	Fludarabine (NSC 118218) CAS:21679-14-1	Fludarabine is an adenosine analong,DNA chain terminator,and inhibitor of ribonucleotide reductase,DNA ligase,DNA primase,and adenoside A1 receptors.It is use to treat leukemias and graft-versus host disease in transplant patients.It also induces cell cycle arrest and apoptosis in alloreactive bone marrow stromal cells.	price>
R-C-1527	SH-4-54 CAS:1456632-40-8	SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5,respectively.SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs)and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.Moreover,in vivo,SH-4-54 exhibited blood-brain barrier permeability,potently controlled glioma tumor growth,and inhibited pSTAT3 in vivo.	price>
R-C-1537	Irbinitinib (ARRY-380) CAS:937263-43-9	Tucatinib(Irbinitinib,ONT-380,ARRY-380)is an oral,potent,selective,reversible and ATP-competitive small-molecule inhibitor of ErbB-2(also called HER2)with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2,respectively in cell-based assays,showing ~500-fold selective for HER2 vs EGFR.It has potential antineoplastic activity.	price>
R-C-1538	CEP-33779 CAS:1257704-57-6	CEP-33779 is a highly selective,orally active,small-molecule inhibitor of JAK2. CEP-33779 induced regression of established colorectal tumors,rRadotinib educed angiogenesis,and reduced proliferation of tumor cells.Tumor regression correlated with inhibition of STAT3 and NF-κB(RelA/p65)activation in a CEP-33779 dose-dependent manner.The ability of CEP-33779 to suppress growth of colorectal tumors by inhibiting the IL-6/JAK2/STAT3 signaling suggests a potential therapeutic utility of JAK2 inhibitors in multiple tumors types, particularly those with a strong inflammatory component.	price>
R-C-1577	FLLL32 CAS:1226895-15-3	FLLL32,a synthetic analog of curcumina,is a JAK2/STAT3 dual inhibitor with anti-tumor activity.FLLL32 can inhibit the induction of STAT3 phosphorylation by IFNα and IL-6 in breast cancer cells.	price>
R-C-1592	Napabucasin (BBI608) CAS:83280-65-3	Napabucasin is a STAT3 inhibitor which blocks stem cell activity in cancer cells.	price>
R-C-1594	GSK 429286A CAS:864082-47-3	GSK429286A is a cell-permeable,selective small molecule inhibitor of Rho-associated,coiled-coil containing protein kinase(ROCK).	price>
R-C-1670	WHI-P258 CAS：21561-09-1	WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72uM.	price>

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