Product apis-jak-stat

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Catalog	name	Description	price
R-R-2413	Stafia-1-dipivaloyloxymethyl ester CAS No.2582755-72-2	Stafia-1-dipivaloyloxymethyl ester (compound 27, 0-200 μM)/CAS No.2582755-72-2 decreases pSTAT5a expression significantly, and has no obvious inhibition on pSTAT5b.	price>
R-R-2414	Eupalinolide K CAS No.108657-10-9	Eupalinolide K/CAS No.108657-10-9, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) .	price>
R-R-2415	W1131 TFA	W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. W1131 inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. W1131 effectively alleviates cancer cell chemoresistance to 5-FU (HY-90006). W1131 regulates the cell cycle, DNA damage response, and oxidative phosphorylation, including the IL6-JAK-STAT3 pathway and the ferroptosis pathway.	price>
R-R-2416	Balsalazide sodium hydrate CAS No.150399-21-6	Balsalazide sodium hydrate/CAS No.150399-21-6 could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.	price>
R-C-717	CYT387（Momelotinib） CAS:1056634-68-4	Momelotinib(CYT387)is an ATP-competitive inhibitor of JAK1/JAK2 with IC50a of 11 nM and 18 nM,respectively.CYT387 shows much less activity against JAK3.	price>
R-R-2417	STAT3-IN-17 CAS No.1245814-52-1	STAT3-IN-17/CAS No.1245814-52-1 is a moderate STAT3 inhibitor (IC50=0.7 μM; HEK-Blue IL-6), with antiproliferative activity in HeLa cells. STAT3-IN-17 has good pharmacokinetic characteristics. STAT3-IN-17 also inhibits pyruvate-ferredoxin oxidoreductase (PFOR), and inhibits Helicobacter pylori.	price>
R-R-2418	MNK8 CAS No.2055078-49-2	MNK8/CAS No.2055078-49-2 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells.	price>
R-R-2419	LY5 CAS No.1436382-03-4	LY5/CAS No.1436382-03-4 is a STAT3 inhibitor with an IC50 value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer.	price>
R-R-2420	Pimozide-d4 CAS No.1803193-57-8	Pimozide-d4/CAS No.1803193-57-8 is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.	price>
R-R-2421	Pimozide-d4-1	Pimozide-d4-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.	price>

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