Product apis-jak-stat

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Catalog	name	Description	price
R-R-2403	C188 CAS No.823828-18-8	C188/CAS No.823828-18-8 is a STAT3 inhibitor that inhibits IL-6-stimulated STAT3 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket. C188, in particular, was highly active in inducing apoptosis of the breast cancer cell line MB-MDA-468 in vitro (EC50= 0.7 μM).	price>
R-R-2404	CMD178 TFA	CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development.	price>
R-R-2405	Stafib-2 CAS No.2097938-74-2	Stafib-2/CAS No.2097938-74-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively. Stafib-2 exhibits poor cell permeability.	price>
R-R-2406	Niclosamide-13C6 CAS No.1325808-64-7	Niclosamide-13C6/CAS No.1325808-64-7 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.	price>
R-R-2407	ML115 CAS No.912798-42-6	ML115/CAS No.912798-42-6 is a molecular probe of the signal transducer and activator of transcription (STAT3). ML115 is a STAT3 agonist.	price>
R-R-2408	Bruceantinol CAS No.53729-52-5	Bruceantinol/CAS No.53729-52-5, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC50=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc.	price>
R-R-2409	Salviolone CAS No.119400-86-1	Salviolone/CAS No.119400-86-1 is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells.	price>
R-R-2410	APTSTAT3-9R	APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity.	price>
R-R-2411	MM-206 CAS No.1809581-87-0	MM-206/CAS No.1809581-87-0, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC50 of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines.	price>
R-R-2412	STAT3-IN-7 CAS No.1313019-65-6	STAT3-IN-7/1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea/CAS No.1313019-65-6 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects.	price>

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