Product apis-jak-stat

Home > products > apis> jak-stat

Catalog	name	Description	price
R-R-2383	NT219 CAS No.1198078-60-2	NT219/CAS No.1198078-60-2 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases.	price>
R-R-2384	STAT5-IN-2 CAS No.2111834-61-6	STAT5-IN-2/CAS No.2111834-61-6 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect.	price>
R-R-2385	UC-514321 CAS No.299420-83-0	UC-514321/CAS No.299420-83-0, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.	price>
R-R-2386	AS2863619 free base CAS No.2241300-50-3	AS2863619 free base/CAS No.2241300-50-3 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene.	price>
R-R-2387	LLL12 CAS No.1260247-42-4	LLL12/CAS No.1260247-42-4 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation. LLL12 enhanced the inhibitory effect of Cisplatin (HY-17394) and Paclitaxel (HY-B0015) on ovarian cancer cell formation, migration, and growth.	price>
R-R-2388	inS3-54A18 CAS No.328998-53-4	inS3-54A18/CAS No.328998-53-4 is a potent STAT3 inhibitor, with anti-cancer properties.	price>
R-R-2389	Golotimod hydrochloride CAS No.1029401-59-9	Golotimod hydrochloride (SCV 07 hydrochloride)/CAS No.1029401-59-9, an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2).	price>
R-R-2390	OSM-SMI-10B	OSM-SMI-10B a derivative of OSM-SMI-10. OSM-SMI-10B significantly reduces OSM-induced STAT3 phosphorylation in cancer cells upon co-incubation with OSM (Oncostatin M).	price>
R-R-2391	PM-43I CAS No.1637532-77-4	PM-43I/CAS No.1637532-77-4 is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research.	price>
R-R-2392	Garcinone C CAS No.76996-27-5	Garcinone C/CAS No.76996-27-5, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner.	price>

...