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Catalog	name	Description	price
R-R-2364	AS2863619 CAS No.2241300-51-4	AS2863619/CAS No.2241300-51-4 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene.	price>
R-R-2365	Corylin CAS No.53947-92-5	Corylin/CAS No.53947-92-5 is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways.	price>
R-R-2366	SI-109 CAS No.2429877-30-3	SI-109/CAS No.2429877-30-3 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36.	price>
R-R-2367	SC-43 CAS No.1400989-25-4	SC-43/CAS No.1400989-25-4, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects.	price>
R-R-2368	Colivelin CAS No.867021-83-8	Colivelin/CAS No.867021-83-8 is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease.	price>
R-R-2369	Fraxinellone CAS No.28808-62-0	Fraxinellone/CAS No.28808-62-0 is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1.	price>
R-R-2370	AS1810722 CAS No.909561-15-5	AS1810722/CAS No.909561-15-5 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research.	price>
R-R-2371	Casticin CAS No.479-91-4	Casticin/CAS No.479-91-4 is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.	price>
R-R-2372	HJC0152 CAS No.1420290-99-8	HJC0152/CAS No.1420290-99-8 is a signal transducers and activators of transcription 3 (STAT3) inhibitor.	price>
R-R-2373	L002 CAS No.321695-57-2	L002/CAS No.321695-57-2 is a potent, cell permeable, reversible and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM. L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation. L002 has the potential for hypertension‐induced cardiac hypertrophy and fibrogenesis treatment.	price>

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