Product apis-jak-stat

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Catalog	name	Description	price
R-R-2355	Homoharringtonine CAS No.26833-87-4	Homoharringtonine (Omacetaxine mepesuccinate;HHT)/CAS No.26833-87-4 is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.	price>
R-R-2356	STAT6-IN-2 CAS No.1355594-85-2	STAT6-IN-2 (Comp R-84)/CAS No.1355594-85-2 is an inhibitor of STAT6. STAT6-IN-2 inhibits the secretion of chemokine eliciting eosinophil infiltration eotaxin-3. STAT6-IN-2 can be used for immune disease research.	price>
R-R-2357	STAT6-IN-3 CAS No.371919-80-1	STAT6-IN-3 (Compound 18a)/CAS No.371919-80-1 is a STAT6 inhibitor (IC50= 44 nM). STAT6-IN-3 targets the Src Homology 2 (SH2) domain of STAT6. STAT6-IN-3 can be used for research of inflammation such as asthma.	price>
R-R-2358	AS1517499 CAS No.919486-40-1	AS1517499/CAS No.919486-40-1 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.	price>
R-C-659	XL019 CAS:945755-56-6	XL019 is a potent,orally active,and selective JAK2 inhibitor,with IC50s of 2.2,134.3,and 214.2 nM for JAK2,JAK1 and JAK3,respectively.XL019 shows 50-fold or greater selectivity for JAK2,versus a panel of over 100 serine/threonine and tyrosine kinases,including other members of the JAK family.XL019 potently inhibits STAT3 and STAT5 phosphorylation in cells harboring either JAK2V617F or wild-type JAK2.	price>
R-R-2359	Cryptotanshinone CAS No.35825-57-1	Cryptotanshinone/CAS No.35825-57-1 is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.	price>
R-R-2360	STAT5-IN-1 CAS No.285986-31-4	STAT5-IN-1/CAS No.285986-31-4 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.	price>
R-R-2361	AC-4-130 CAS No.1834571-82-2	AC-4-130/CAS No.1834571-82-2 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML).	price>
R-R-2362	SD-36 CAS No.2429877-44-9	SD-36/CAS No.2429877-44-9 is a potent and efficacious STAT3 PROTAC degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase. SD-36 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-2363	2-NP CAS No.65182-56-1	2-NP/CAS No.65182-56-1 is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells.	price>

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