Product apis-jak-stat

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Catalog	name	Description	price
R-R-2335	Povorcitinib phosphate CAS No.1637677-33-8	Povorcitinib (INCB54707) phosphate/CAS No.1637677-33-8 is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib phosphate can be used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) (information extracted from patent WO2021076124A1).	price>
R-R-2336	JAK-IN-3 CAS No.1400876-94-9	JAK-IN-3 (compound 22)/CAS No.1400876-94-9 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.	price>
R-R-2337	JAK-IN-1 CAS No.1334673-53-8	JAK-IN-1/CAS No.1334673-53-8 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. JAK-IN-1 shows improved selectivity for JAK3 over JAK1.	price>
R-R-2338	JAK-IN-26 CAS No.2417134-93-9	JAK-IN-26 (compound 2)/CAS No.2417134-93-9 is an orally active JAK inhibitor with good pharmacokinetic characteristics. JAK-IN-26 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=17.2 nM).	price>
R-R-2339	GS-829845 CAS No.1257705-09-1	GS-829845/CAS No.1257705-09-1 is a major, active metabolite of Filgotinib (HY-18300). GS-829845 is a JAK1 preferential inhibitor but is approximately 10-fold less potent than the parent and with a longer half-life.	price>
R-R-2340	SJ1008030 formic	SJ1008030 (compound 8) formic is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 formic inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 formic can be used for the research of leukemia.	price>
R-R-2341	Itacnosertib (hydrocholide) CAS No.2409543-84-4	Itacnosertib hydrocholide/CAS No.2409543-84-4 is an inhibitor of JAK2, ACVR1 (ALK2) and ALK5.	price>
R-R-2342	(R,R)-VVD-118313 CAS No.2875046-31-2	(R,R)-VVD-118313/CAS No.2875046-31-2 is the isomer of VVD-118313 (HY-151385). VVD-118313 is a selective JAK1 inhibitor and blocks JAK1-dependent trans-phosphorylation and cytokine signaling. VVD-118313 can be used for research of cancer. (R,R)-VVD-118313 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-2343	GDC-4379 CAS No.2252277-73-7	GDC-4379/CAS No.2252277-73-7 is a JAK1 inhibitor that can be used for the research of asthma.	price>
R-R-2344	Tubulin/JAK2-IN-1 CAS No.2933938-46-4	Tubulin/JAK2-IN-1 (compound 7g)/CAS No.2933938-46-4 is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. Tubulin/JAK2-IN-1 has potent antiproliferative activity against the cancer cells.	price>

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