Product apis-jak-stat

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Catalog	name	Description	price
R-R-2374	Stafia-1 CAS No.2582757-90-0	Stafia-1/CAS No.2582757-90-0 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.	price>
R-C-675	SB1518(Pacritinib) cas:937272-79-2	Pacritinib,also known as SB1518,is an orally bioavailable inhibitor of Janus kinase 2(JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity.Pacritinib competes with JAK2 for ATP binding,which may result in inhibition of JAK2 activation,inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.	price>
R-R-2375	Mogrol CAS No.88930-15-8	Mogrol/CAS No.88930-15-8 is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.	price>
R-R-2376	YM-341619 CAS No.643082-52-4	YM-341619 (AS1617612)/CAS No.643082-52-4 is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC50=0.28 nM) without affecting Th1 cell differentiation. YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma.	price>
R-R-2377	Picroside I CAS No.27409-30-9	Picroside I/CAS No.27409-30-9 is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ.	price>
R-R-2378	Stafib-1 CAS No.1688703-26-5	Stafib-1/CAS No.1688703-26-5 is the first selective inhibitor of the STAT5b SH2 domain, with a Ki of 44 nM and an IC50 of 154 nM.	price>
R-R-2379	Ochromycinone CAS No.111540-00-2	Ochromycinone ((Rac)-STA-21)/CAS No.111540-00-2 is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity.	price>
R-R-2380	NSC-370284 CAS No.116409-29-1	NSC-370284/CAS No.116409-29-1 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5.	price>
R-R-2381	STX-0119 CAS No.851095-32-4	STX-0119/CAS No.851095-32-4 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.	price>
R-R-2382	Angoline CAS No.21080-31-9	Angoline/CAS No.21080-31-9 is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.	price>

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