Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-C-1476	MK-3697 CAS:1224846-01-8	MK-3697 is a highly potent,orally bioavailable selective orexin 2 receptor antagonists.MK-3697 is also the third insomnia drug,currently being developed by Merck.MK-3697 has Ki=0.95nM.Orexin receptor antagonists have demonstrated clinical utility for the treatment of insomnia.In vivo tests results on MK-3697 demonstrated improved stability and TDI profiles as well as excellent sleep efficacy across species.	price>
R-R-3176	Zacopride hydrochloride CAS No.101303-98-4	Zacopride hydrochloride/CAS No.101303-98-4 is a highly potent 5-HT3 receptor antagonist with Kis of 0.38 and 373 nM for 5-HT3 and 5-HT4 receptor, respectively. Zacopride hydrochloride is also a moderate IK1 channel agonist. Zacopride hydrochloride exerts significant antiarrhythmic and cardiac protective effects.	price>
R-R-3177	Flibanserin CAS No.167933-07-5	Flibanserin (BIMT-17; BIMT-17BS)/CAS No.167933-07-5 is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-.	price>
R-R-3178	Iloperidone CAS No.133454-47-4	Iloperidone (HP 873)/CAS No.133454-47-4 is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms.	price>
R-R-3179	Naratriptan hydrochloride CAS No.143388-64-1	Naratriptan hydrochloride/CAS No.143388-64-1 is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches.	price>
R-R-3180	Quipazine CAS No.4774-24-7	Quipazine/CAS No.4774-24-7 is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine behaves as a 5-HT3R agonist in peripheral models. Quipazine can be used for neurological disease research.	price>
R-R-3181	NAN-190 hydrobromide CAS No.115338-32-4	NAN-190 hydrobromide/CAS No.115338-32-4 is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.	price>
R-R-3182	Mirtazapine-d3 CAS No.1216678-68-0	Mirtazapine-d3/CAS No.1216678-68-0 is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors.	price>
R-R-3183	WAY-181187 CAS No.554403-49-5	WAY-181187 (SAX-187)/CAS No.554403-49-5 is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist.	price>
R-R-3184	SB 243213 CAS No.200940-22-3	SB 243213/CAS No.200940-22-3 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.	price>

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